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Progestagen Type in Postmenopausal Hormone Therapy and Blood Gene Expression Profile

2014-08-27 03:13:41 | BioPortfolio

Summary

The purpose of this study is to compare combined postmenopausal hormone therapy natural progesterone to the one containing synthetic progestagen (i.e. chlormadinone acetate) at the blood transcriptome level.

Study Design

Allocation: Randomized, Control: Active Control, Intervention Model: Parallel Assignment, Masking: Open Label

Conditions

Pharmacogenomics

Intervention

Progesterone, Chlormadinone acetate

Location

Gynecology center, Helse Nord
Bodø
Norway

Status

Recruiting

Source

University Hospital of North Norway

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:41-0400

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Medical and Biotech [MESH] Definitions

An orally active synthetic progestational hormone used often in combinations as an oral contraceptive.

A 6-methyl PROGESTERONE acetate with reported glucocorticoid activity and effect on ESTRUS.

17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.

Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.

Steroidal compounds related to PROGESTERONE, the major mammalian progestational hormone. Progesterone congeners include important progesterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with progestational activities.

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