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This is a hospital-based interventional prospective study. Patients with clinical keratoconus or LASIK keratectasia presenting to the Singapore National Eye Centre who meet the eligibility criteria are recruited for this study. The aim of the study is to assess the safety and efficacy of riboflavin-UVA induced cross-linking treatment for corneal ectasia
The purpose of this evaluation is to assess the safety and efficacy of riboflavin-UVA induced cross-linking treatment for corneal ectasia due to keratoconus and LASIK keratectasia. The principle of the procedure is to induce collagen crosslinking of the corneal stroma by the using riboflavin/UVA-treatment.
The technique involves topical application of riboflavin/dextran solution onto eye after removal of corneal epithelium. After initial riboflavin application for 30 minutes, UVA light is shone onto the cornea for another 30 minutes with continued topical riboflavin application.
A thorough examination is performed to evaluate the following pre-operatively:
- Manifest refraction results - Uncorrected visual acuity (UCVA) and best corrected visual acuity (BCVA)
- Cycloplegic refraction results - Uncorrected visual acuity (UCVA) and best corrected visual acuity (BCVA)
- Slit-lamp biomicroscopy and photography
- Intraocular pressure measurement
- Corneal topography using Orbscan II and Pentacam
- Corneal aberrometry measurement using Technolas Zywave Aberrometer
- Endothelial cell count measurement using Konan noncontact endothelial cell analyser
- Confocal microscopy
- Corneal hysteresis measurement using Ocular Response Analyser
- Subjective feedback about quality of vision (VF 14 assessment) Post-operative Assessment (1 day, 1 week, 1 month, 3 months, 6 months and 1 year postoperatively)
- Uncorrected visual acuity and best corrected visual acuity with manifest refraction
- Cycloplegic refraction results - uncorrected visual acuity and best corrected visual acuity
- Subjective visual outcome rating
- Slit lamp examination and photography
- Corneal topography
- Aberrometry measurement
- Endothelial cell count
- Confocal microscopy
- Corneal hysteresis measurement
- Report adverse events
Allocation: Non-Randomized, Control: Uncontrolled, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
riboflavin-induced collagen cross-linking treatment, Riboflavin-UVA induced collagen cross-linking treatment for corneal ectasia
Singapore Eye Research Institute
Singapore National Eye Centre
Published on BioPortfolio: 2014-08-27T03:13:41-0400
Cross-linking of the cornea increases the mechanical and biochemical stability of the stromal tissue. The purpose of this study is to assess the effectiveness of riboflavin-ultraviolet lig...
Corneal ectasia is a relative weakness in the structure of the cornea, which produces a progressive change in its shape which results in visual distortion. It is known that collagen cross...
Following the Bunsen-Roscoe law, accelerated cross-linking protocols with higher irradiation intensities and shorter irradiation times have been introduced. In addition, new riboflavin sol...
Prospective, randomized multicenter study to determine the safety and effectiveness of performing corneal collagen cross-linking (CXL) using riboflavin and UVA light in eyes with ectasia a...
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To compare intraoperative changes in central corneal thickness (CCT) during corneal cross-linking, using 2 different isotonic riboflavin solutions either with dextran or with hydroxy propyl methylcell...
To investigate riboflavin concentration on enzymatic resistance following corneal cross-linking (CXL).
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An enzyme that catalyzes the formation of riboflavin from two molecules of 6,7-dimethyl-8-ribityllumazine, utilizing a four-carbon fragment from one molecule which is transferred to the second molecule. EC 184.108.40.206.
A dietary deficiency of riboflavin causing a syndrome chiefly marked by cheilitis, angular stomatitis, glossitis associated with a purplish red or magenta-colored tongue that may show fissures, corneal vascularization, dyssebacia, and anemia. (Dorland, 27th ed)
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Artificially induced UTERINE CONTRACTION. Generally, LABOR, OBSTETRIC is induced with the intent to cause delivery of the fetus and termination of pregnancy.
A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
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Ophthalmology is the branch of medicine that is devoted to the study and treatment of eye diseases. As well as mild visual defects correctable by lenses, ophthalmology is concerned with glaucoma, uveitis and other serious conditions affecting the eye, ...