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Pharmacokinetics and Pharmacodynamics of Intravenous Artesunate for Severe Malaria Treatment

2014-08-27 03:13:46 | BioPortfolio

Summary

Intravenous artesunate is highly effective with rapid schizonticidal action and improved clinical outcome

Description

The current first line treatment for severe malaria in Uganda is intravenous quinine with artemisinin derivatives as an alternative. Intravenous artesunate, a water soluble artemisinin derivative is more effective than quinine with faster schizonticidal action and improved clinical outcome. It is generally well tolerated and safe. This study aims is to assess the pharmacokinetics, pharmacodynamics and safety of IV artesunate in treatment of severe malaria in adults admitted to Mulago National Referral and Teaching hospital, Uganda.

Study Design

Time Perspective: Prospective

Conditions

Severe Malaria

Intervention

intravenous artesunate

Location

Mulago National Referral hospital
Kampala
Uganda
256

Status

Not yet recruiting

Source

Makerere University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:46-0400

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PubMed Articles [5742 Associated PubMed Articles listed on BioPortfolio]

Optimal Treatments for Severe Malaria and the Threat Posed by Artemisinin Resistance.

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Associations between erythrocyte polymorphisms and risks of uncomplicated and severe malaria in Ugandan children: A case control study.

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Medical and Biotech [MESH] Definitions

Malaria caused by PLASMODIUM VIVAX. This form of malaria is less severe than MALARIA, FALCIPARUM, but there is a higher probability for relapses to occur. Febrile paroxysms often occur every other day.

Vaccines made from antigens arising from any of the four strains of Plasmodium which cause malaria in humans, or from P. berghei which causes malaria in rodents.

A protozoan parasite that causes vivax malaria (MALARIA, VIVAX). This species is found almost everywhere malaria is endemic and is the only one that has a range extending into the temperate regions.

Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.

A protozoan parasite that occurs naturally in the macaque. It is similar to PLASMODIUM VIVAX and produces a type of malaria similar to vivax malaria (MALARIA, VIVAX). This species has been found to give rise to both natural and experimental human infections.

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