Early Vitrectomy for Impending Macular Hole

2014-07-23 21:09:06 | BioPortfolio


This study is designed to verify hypothesis that early vitrectomy may prevent impending macular hole from progression to full-thickness macular hole.


In a study conducted 15 years ago, the 'Vitrectomy for Prevention of Macular hole Study Group' was not able to prove the benefits and advantages of vitrectomy for impending macular hole; however, during the interim period, notable improvements have been achieved with regard to diagnosis and efficacy of treatment.

Therefore, we designed this study to identify the effect of current vitreous surgery for symptomatic impending macular hole.

Characteristics of this study is as below

- Multicenter, prospective clinical trial. (early surgical intervention vs.surgical intervention when full-thickness macular hole occurs)

- Non-randomized study (decision was made by patients after full explanation)

- After 1 year follow up, functional change(visual acuity)and anatomical change(development of full-thickness macular hole) would be evaluated

Study Design

Allocation: Non-Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment


Retinal Perforation


Pars plana vitrectomy with ILM peeling


Asan Medical Center, University of Ulsan College of Medicine
Korea, Republic of




Seoul Retina Investigator Group

Results (where available)

View Results


Published on BioPortfolio: 2014-07-23T21:09:06-0400

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PubMed Articles [1436 Associated PubMed Articles listed on BioPortfolio]

Comparison of pars plana vitrectomy for retinal detachment after failed pneumatic retinopexy and primary pars plana vitrectomy.

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To report a case of branch retinal artery wall rupture and subsequent branch retinal artery occlusion occurring during a routine pars plana vitrectomy with epiretinal membrane and internal limiting me...

Biomarkers and predictors for functional and anatomic outcomes for small gauge pars plana vitrectomy and peeling of the internal limiting membrane in naïve diabetic macular edema: The VITAL Study.

We aimed to investigate biomarkers and predictive factors for visual and anatomical outcome in patients with naïve diabetic macular edema (DME) who underwent small gauge pars plana vitrectomy (PPV) w...

Macular Hole Formation After Pars Plana Vitrectomy for Diabetic Tractional Retinal Detachment.

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Internal limiting membrane peeling versus no peeling during primary vitrectomy for rhegmatogenous retinal detachment: A systematic review and meta-analysis.

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Medical and Biotech [MESH] Definitions

Form of granulomatous uveitis occurring in the region of the pars plana. This disorder is a common condition with no detectable focal pathology. It causes fibrovascular proliferation at the inferior ora serrata.

Inflammation of the pars plana, ciliary body, and adjacent structures.

Removal of the whole or part of the vitreous body in treating endophthalmitis, diabetic retinopathy, retinal detachment, intraocular foreign bodies, and some types of glaucoma.

A region in the substantia nigra located dorsal to the PARS RETICULATA.

A region in the substantia nigra located ventral and lateral to the PARS COMPACTA.

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