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8 healthy male volunteers will be studied each on 3 occasions, ie
- after 4 days on a weight maintenance diet containing 5% simple sugars + low physical activity
- after 4 days on a weight maintenance diet containing 30% fructose + low physical activity
- after 4 days on a weight maintenance diet containing 30% fructose + high physical activity At the end of each of these 3 periods, fructose induced hepatic de novo lipogenesis (13C palmitate synthesis in response to ingestion of a 13C fructose load) and plasma VLDL-triglyceride kinetics (measured with a bolus of 2H-labeled glycerol) will be measured
Allocation: Randomized, Control: Uncontrolled, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
weight maintenance, low sugar diet, weight maintenance, high fructose diet, weight maintenance, high fructose diet+ exercise
Centre Hospitalier Universitaire Vaudois
University of Lausanne
Published on BioPortfolio: 2014-08-27T03:13:47-0400
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