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PURPOSE: This clinical trial is studying the genes biomarkers in children with neuroblastoma.
- Evaluate the independent association of common genetic polymorphisms involved in folate, vitamin A, and related metabolic and transport pathways and the risk of neuroblastoma (NB) in children who were diagnosed before age 6.
- Evaluate the joint effects of multiple genes on the risk of NB.
- Evaluate the effects of gene-exposure interactions, with primary interest on folate, vitamin A, and choline intake, on the risk of NB.
- Evaluate genetic effects within NB subgroups defined by age at diagnosis and a Children's Oncology group classification schema based on age, MYCN oncogene status, histology, and DNA ploidy.
OUTLINE: This is a multicenter study.
The biologic mother of the patient is asked to complete a Diet History Questionnaire about diet during pregnancy, and information on demographics, lifestyle factors, medication used during pregnancy, history of breast feeding, and family history of cancer or birth defects.
Parents are given buccal cell collection kits for self-collection. Buccal cell samples are collected from both biologic parents and the patient. Tissue samples previously stored in a tissue bank are obtained for deceased patients, if available. DNA is extracted from samples, amplified and analyzed using real-time PCR quantitation assay, and genotyped using single nucleotide polymorphisms.
DNA analysis, cytogenetic analysis, polymerase chain reaction, polymorphism analysis, questionnaire administration, study of socioeconomic and demographic variables
Not yet recruiting
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:13:52-0400
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