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Hämeenlinna Metabolic Syndrome Research Program: Surrogate Indicators for Atherosclerosis

2014-08-27 03:13:52 | BioPortfolio

Summary

Mechanisms that link metabolic syndrome to atherosclerosis are incompletely understood. As a part of Hämeenlinna Metabolic Syndrome Research Program (HMS) surrogate indicators for atherosclerosis are studied in 120 men with metabolic syndrome, 120 men with coronary heart disease and 80 physically active controls and in different settings.

Description

Accumulation of oxidized low-density lipoproteins (LDL) in the intimae of arteries together with risk factors known to enhance atherosclerosis, damage the endothelium of the arterial wall. Dysfunction of the endothelium leads into loss of elasticity of the artery. Surrogate indicators of atherosclerosis might be seen already in the early phase of otherwise subclinical arterial disease.

In this study, we investigate calculated risk of the subjects (SCORE, FINRISK, Framingham score), platelet function and surrogate indicators for atherosclerosis like erectile dysfunction, plasma levels of oxidized LDL, arterial elasticity and biochemical markers for endothelial damage and dysfunction in different settings (case-only and case-control).

Study Design

Time Perspective: Cross-Sectional

Conditions

Metabolic Syndrome

Location

Finnish Red Cross Blood Transfusion Service
Helsinki
Finland
00310

Status

Recruiting

Source

Central Hospital of Kanta-Hame

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:52-0400

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