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Bright Light as a Countermeasure for Circadian Desynchrony

2014-08-27 03:13:52 | BioPortfolio

Summary

Light is the primary means by which the internal circadian clock remains aligned ("entrained") with the external world. Misalignment of this internal clock can occur during situations such as shift work and jet travel across multiple time zones (jet lag). The purpose of this study is to examine the parameters of light and how they affect entrainment of the clock.

Study Design

Allocation: Randomized, Control: Dose Comparison, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Conditions

Healthy

Intervention

Bright light

Location

VA Palo Alto Health Care System
Palo Alto
California
United States
94304

Status

Not yet recruiting

Source

VA Palo Alto Health Care System

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:52-0400

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PubMed Articles [9023 Associated PubMed Articles listed on BioPortfolio]

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Medical and Biotech [MESH] Definitions

Relatively bright light, or the dazzling sensation of relatively bright light, which produces unpleasantness or discomfort, or which interferes with optimal VISION, OCULAR. (Cline et al., Dictionary of Visual Science, 4th ed)

Combustion or burning in which substances combine chemically with oxygen typically giving out bright light, heat, and smoke.

Light-induced change in a chromophore, resulting in the loss of its absorption of light of a particular wave length. The photon energy causes a conformational change in the photoreceptor proteins affecting PHOTOTRANSDUCTION. This occurs naturally in the retina (ADAPTATION, OCULAR) on long exposure to bright light. Photobleaching presents problems when occurring in PHOTODYNAMIC THERAPY, and in FLUORESCENCE MICROSCOPY. On the other hand, this phenomenon is exploited in the technique, FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING, allowing measurement of the movements of proteins and LIPIDS in the CELL MEMBRANE.

Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.

Failure or imperfection of vision at night or in dim light, with good vision only on bright days. (Dorland, 27th ed)

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