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The purpose of this study is to find out the effects of using a system called CliniMACS to remove Tcells from blood stem cells. Removing T-cells may help stop a side effect called Graft-Versus-Host Disease (GVHD). Some studies have been done with CliniMACS, but the Food and Drug Administration (FDA) has not yet approved it.
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Acute Lymphoblastic Leukemia
CliniMACS Fractionation system, CliniMACS Fractionation system, CliniMACS Fractionation system
Memorial Sloan Kettering Cancer Center
Memorial Sloan-Kettering Cancer Center
Published on BioPortfolio: 2014-08-27T03:13:53-0400
The aim of our study was to evaluate the value of two different altered fractionation schedules – hyperfractionation and accelerated fractionation with concomitant boost – in compariso...
T cell depletion utilizing the CliniMACS device will allow more precise, specific and controlled graft engineering of peripheral blood stem cells from unrelated and partially matched relat...
To assess the proportion of patients with donor neutrophil engraftment within 30 days of allogeneic transplant. To assess the incidence of acute GvHD during the first 100 days after trans...
This is a single arm pilot study for patients with hematologic malignancies with alternative donor sources receiving unrelated or partially matched related/Haploidentical mobilized periphe...
This is a pilot study with 2 strata to evaluate engraftment and graft vs. host disease (GVHD) in patients receiving unrelated or partially matched related donor peripheral stem cells with ...
This SOP describes a closed system for isolating GMP-grade CD4CD25 T cells from non-mobilized leukapheresis collections (nMLCs), independent of a clean room in a certified GMP premises, by using Clini...
Chromium isotope fractionation analysis is a promising approach for the assessment of microbial Cr(VI) reduction in groundwater. Understanding the mechanisms and other parameters that control Cr isoto...
Tributyl phosphate (TBP) belongs to the group of trialkyl substituted organophosphate esters. Its chemical reactivity depends on the stability of various chemical bonds. TBP was used as a model compou...
Graphene oxide (GO) is not only a uniqe class of two-dimensional materials but also an important precursor for scalable preparation of graphene. The efficient size fractionation of graphene oxide is o...
Interactions between dissolved organic matter (DOM) and iron oxyhydroxides have important environmental and geochemical implications. The present study employed two hematite nanocrystals to investigat...
Sulfuric acid diammonium salt. It is used in CHEMICAL FRACTIONATION of proteins.
Techniques to partition various components of the cell into SUBCELLULAR FRACTIONS.
Administration of the total dose of radiation (RADIATION DOSAGE) in parts, at timed intervals.
Pinched-off nerve endings and their contents of vesicles and cytoplasm together with the attached subsynaptic area of the membrane of the post-synaptic cell. They are largely artificial structures produced by fractionation after selective centrifugation of nervous tissue homogenates.
Separation of a mixture in successive stages, each stage removing from the mixture some proportion of one of the substances, for example by differential solubility in water-solvent mixtures. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Food is any substance consumed to provide nutritional support for the body. It is usually of plant or animal origin, and contains essential nutrients, such as carbohydrates, fats, proteins, vitamins, or minerals. The substance is ingested by an organism ...
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...