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Safety Study of Live Bacteria to Treat Solid Tumors That Have Not Responded to Standard Therapy

2014-08-27 03:13:53 | BioPortfolio

Summary

This protocol will examine the safety of treating subjects with Clostridium novyi-NT spores in patients with treatment-refractory solid tumor malignancies. This pilot study will investigate the safety of using a sepsis scoring system to determine when to initiate antibiotics in these patients.

Study Design

Allocation: Non-Randomized, Control: Uncontrolled, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Solid Tumor Malignancies

Intervention

Clostridium novyi-NT spores

Location

Sidney Kimmel Comprehensice Cancer Center
Baltimore
Maryland
United States
21231

Status

Recruiting

Source

Sidney Kimmel Comprehensive Cancer Center

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:53-0400

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PubMed Articles [9903 Associated PubMed Articles listed on BioPortfolio]

Biofilm-derived spores of Clostridioides (Clostridium) difficile exhibit increased thermotolerance compared to planktonic spores.

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Development of an optimized broth enrichment culture medium for the isolation of Clostridium difficile.

Clostridium difficile is a spore forming bacterium and the leading cause of colitis and antibiotic associated diarrhoea in the developed world. Effective recovery of spores, particularly in low number...

Multiple functions of Ikaros in hematological malignancies, solid tumor and autoimmune diseases.

Ikaros, encoded by IKZF1 (Ikaros family zinc finger 1), is an important transcription factor in the control of lymphocyte specification and differentiation. Multiple functions of Ikaros have been exer...

Increased environmental sample area and recovery of Clostridium difficile spores from hospital surfaces by quantitative PCR and enrichment culture.

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Medical and Biotech [MESH] Definitions

An alkylating agent of value against both hematologic malignancies and solid tumors.

A species of gram-positive bacteria in the family Clostridiaceae. Infections have a strong association with malignancies and also with GAS GANGRENE.

Heat and stain resistant, metabolically inactive bodies formed within the vegetative cells of bacteria of the genera Bacillus and Clostridium.

A species of gram-positive bacteria in the family Clostridiaceae isolated from infected CATTLE; SHEEP; and other animals. It causes blackleg in cattle and sheep and is transmitted through soil-borne spores.

A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.

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