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Hypertonic Saline (6%) Versus Isotonic Saline (0.9%) in Bronchiectasis

2014-08-27 03:14:06 | BioPortfolio

Summary

The investigators hypothesise that nebulised hypertonic saline (6%) will increase the volume of sputum expectorated over a 24 hour period compared to nebulised isotonic saline (0.9%) in patients with mild to severe stable bronchiectasis.

Study Design

Allocation: Randomized, Control: Placebo Control, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Conditions

Bronchiectasis

Intervention

Hypertonic saline, Isotonic saline

Location

Belfast HSCT
Belfast
Northern Ireland
United Kingdom
BT9 7AB

Status

Recruiting

Source

Belfast Health and Social Care Trust

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:06-0400

Clinical Trials [1923 Associated Clinical Trials listed on BioPortfolio]

The Long Term Effect of Inhaled Hypertonic Saline (6%) in Patients With Non Cystic Fibrosis Bronchiectasis

The purpose of this study is to determine whether the daily inhalation of nebulised hypertonic saline (6%) will decrease the incidence of pulmonary exacerbations and increase the quality o...

Saline Hypertonic in Preschoolers

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Saline Hypertonic in Preschoolers + CT

The purpose of this study is to assess whether inhalation of 7% hypertonic saline (HS) twice daily for 48 weeks reduces structural lung disease as assessed by computed tomography (CT) in c...

The Effect of Hypertonic Saline on the Lung Clearance Index in Patients With Cystic Fibrosis

This study is examining the effect of hypertonic saline compared to placebo on the Lung Clearance Index in Cystic Fibrosis patients.

Hypertonic Resuscitation Following Traumatic Brain Injury

The purpose of this study is to determine if hypertonic saline with and without dextran can improve neurologic outcomes in victims of severe traumatic brain injury (TBI). Injury and lost ...

PubMed Articles [834 Associated PubMed Articles listed on BioPortfolio]

Impact of Hypertonic Saline Solutions on Sputum Expectoration and Their Safety Profile in Patients with Bronchiectasis: A Randomized Crossover Trial.

The role of hyaluronic acid plus hypertonic saline (HA+HS) as a mucoactive treatment in patients with bronchiectasis is still unknown. This study evaluated whether HA+HS solution enhances similar sput...

Initial Fluid Therapy in Pediatric Diabetic Ketoacidosis: A comparison of Hypertonic Saline Solution and Normal Saline Solution.

The optimal fluid therapy in children with DKA is a matter of debate, especially if we take into account its association with cerebral edema, the most important complication. Hypertonic Saline Solutio...

Intravenous Hypertonic Saline to Lower Intraocular Pressure in Ocular Hypertension and Primary Open-angle and Exfoliation Glaucoma.

To quantitate the effect of intravenous hypertonic saline on elevated intraocular pressure (IOP) among three groups of glaucoma patients or suspects.

Recipient hypertonic saline infusion prevents cardiac allograft dysfunction.

Hypertonic saline (HTS) has potent immune and vascular effects. We assessed recipient pretreatment with HTS on allograft function in a porcine model of heart transplantation and hypothesized that HTS ...

Hypertonic saline-hydroxyethyl starch solution attenuates fluid accumulation in cardiac surgery patients: a randomized controlled double-blind trial.

Significant fluid retention is common after cardiac surgery with the use of cardiopulmonary bypass (CPB). The aim of the study was to evaluate the effects of hypertonic saline-hydroxyethyl starch (HS-...

Medical and Biotech [MESH] Definitions

Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).

A genus of HALOBACTERIACEAE distinguished from other genera in the family by the presence of specific derivatives of TGD-2 polar lipids. Haloarcula are found in neutral saline environments such as salt lakes, marine salterns, and saline soils.

A family of gram-negative, moderately halophilic bacteria in the order Oceanospirillales. Members of the family have been isolated from temperate and Antarctic saline lakes, solar salt facilities, saline soils, and marine environments.

A species of PERCIFORMES commonly used in saline aquaculture.

Water from natural sources which contain significant concentrations of dissolved salts such as sodium chloride.

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