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Bronchodilator Responsiveness in Bronchiolitis Obliterative Syndrome (BOS)

2014-08-27 03:14:07 | BioPortfolio

Summary

This study has been designed to provide a substantial evidence of acute bronchodilator responsiveness to two sequentially inhaled drugs, a beta2-agonist (i.e., albuterol) and an anticholinergic (i.e., tiotropium bromide), in a group of patients who developed bronchiolitis obliterative syndrome after hematopoietic stem cell transplantation.

Description

Bronchiolitis obliterative syndrome (BOS) is a life-threatening non-infectious pulmonary complication of allogeneic hematopoietic stem cell transplantation (HSCT). It is characterized by the development of an obstructive abnormality which has been considered to be insensitive to bronchodilator treatments. However, this knowledge stems from measurements of forced expiratory volume in 1 s (FEV1) which is relatively insensitive to changes in small airway caliber. Moreover, it is known from studies in chronic obstructive pulmonary disease (COPD) that symptoms improve after bronchodilator treatment even when FEV1 is minimally increased and correlate with the reduction of lung hyperinflation, which is the major consequence of severe expiratory airflow limitation. Therefore, measurements of airway caliber by parameters not affected by volume history and absolute lung volumes are preferable for assessing the effect of bronchodilator interventions.

In the current study, the bronchodilators responsiveness will be assessed by using not only spirometry but also measurements of absolute lung volumes and the forced expiratory flow of a partial maneuver (V'part) started from submaximal lung inflation, thus free of volume history effects.

Study Design

Control: Active Control, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Conditions

Bronchiolitis Obliterative Syndrome

Intervention

albuterol plus tiotropium

Location

Unit of Preventive and Occupational Medicine - Laboratory of Respiratory Pathophysiology, University Hospital San Martino
Genoa
Italy
16132

Status

Recruiting

Source

Azienda Ospedaliera Universitaria San Martino

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:07-0400

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