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Study of Human Leukocyte Antigen (HLA) Polymorphisms in Patients With Rheumatoid Arthritis

2014-08-27 03:14:11 | BioPortfolio

Summary

Rheumatoid arthritis (RA), affects between 0.3% and 1.0% of the population, it can lead to progressive joint destruction and severe disability. To date, two RA genetic susceptibility factors have been identified: HLA-DRB1-SE (Shared epitope) and PTPN22 620W alleles. The predictive value of the alleles for diagnosis of RA was previously investigated in cohorts of caucasians patients with early unclassified arthritis that showed restrained association between RA and HLA-SE. Despite the contribution of HLA to the overall genetic risk has been estimated to range from 30% to 50%, it has never been studied in the French west-Indian population.

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Conditions

Rheumatoid Arthritis

Intervention

Collect of 10 ml of peripheric blood for DNA extraction

Location

Service de rhumatologie CHU de Fort-de-France
Fort-de-France
Martinique
97261

Status

Enrolling by invitation

Source

Centre Hospitalier Universitaire de Fort-de-France

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:11-0400

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