Prevention of Ventricular Dysfunction During Chemotherapy

2014-07-23 21:09:26 | BioPortfolio


The investigators' objective is to assess the effect of the combined treatment of enalapril and carvedilol in the prevention of cardiac dysfunction in patients with hematological malignancies submitted to intensive chemotherapy.

The hypothesis is that these drugs administered during chemotherapy may prevent cardiac dysfunction.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention


Acute Leukemia


Enalapril plus carvedilol


Hospital Clinic




Hospital Clinic of Barcelona

Results (where available)

View Results


Published on BioPortfolio: 2014-07-23T21:09:26-0400

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Medical and Biotech [MESH] Definitions

A rare acute myeloid leukemia characterized by abnormal EOSINOPHILS in the bone marrow.

An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.

An acute leukemia exhibiting cell features characteristic of both the myeloid and lymphoid lineages and probably arising from MULTIPOTENT STEM CELLS.

Conditions in which the abnormalities in the peripheral blood or bone marrow represent the early manifestations of acute leukemia, but in which the changes are not of sufficient magnitude or specificity to permit a diagnosis of acute leukemia by the usual clinical criteria.

An acute myeloid leukemia in which 80% or more of the leukemic cells are of monocytic lineage including monoblasts, promonocytes, and MONOCYTES.

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