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The Efficacy of Oral Versus Intravenous Hypertonic Saline Administration in Runners With Exercise-Associated Hyponatremia

2014-08-27 03:14:11 | BioPortfolio

Summary

The purpose of the study is to 1) evaluate incidence and primary cause of exercise-associated Hyponatremia (EAH) in race finishers participating in the Western States 100-mile Endurance Run, 2) determine if the ingestion of oral hypertonic saline (high salt) is as effective as intravenous administration of hypertonic saline to elevate below-normal blood salt concentrations (EAH) at the end of the Western States Endurance Run, and 3) determine if oral and intravenous hypertonic saline solutions are equally as effective at reversing mild (without altered mental status) symptoms associated with EAH.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Exercise-associated Hyponatremia

Intervention

Intravenous hypertonic Saline, Oral hypertonic saline

Location

Western States Endurance Run
Sacramento
California
United States
95835

Status

Recruiting

Source

Western States Endurance Run Research Foundation

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:11-0400

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A family of gram-negative, moderately halophilic bacteria in the order Oceanospirillales. Members of the family have been isolated from temperate and Antarctic saline lakes, solar salt facilities, saline soils, and marine environments.

Solutions that have a greater osmotic pressure than a reference solution such as blood, plasma, or interstitial fluid.

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