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Study in Chronic Kidney Disease (CKD) Not on Dialysis

2014-08-27 03:14:11 | BioPortfolio

Summary

The objective of this study is to investigate the efficacy and safety of lanthanum carbonate 750 to 2,250 mg in Japanese Chronic Kidney Disease Stage 3, 4 and 5 subjects not on dialysis.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Conditions

Hyperphosphatemia

Intervention

Fosrenol (Lanthanum Carbonate, BAY77-1931), Placebo

Location

Nagoya
Aichi
Japan
455-8530

Status

Recruiting

Source

Bayer

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:11-0400

Clinical Trials [155 Associated Clinical Trials listed on BioPortfolio]

Bioequivalence Study of BAY 77-1931 Orally Disintegrating Tablet

The primary objective of this study was to establish the bioequivalence of two different tablet formulations containing BAY77-1931. The secondary objectives of this study were to assess th...

Fosrenol Post-marketing Surveillance for Hemodialysis in Japan

This study is a regulatory post marketing surveillance in Japan, and it is a local prospective and observational study of patients in hemodialysis who received Fosrenol for hyperphosphatem...

Long-Term Treatment on Bay 77-1931 (Lanthanum Carbonate) to Measure Lanthanum Concentrations in Bone

To measure lanthanum concentrations in bone in patients with hyperphosphatemia receiving dialysis

Long-Term Effect of Lanthanum Carbonate on Bone

Patients enrolled in a previous study (SPD405-309), who were exposed to lanthanum carbonate (Fosrenol), were eligible to continue on any prescribed treatment for hyperphosphatemia, includi...

Long Term Treatment of End Stage Renal Disease Patients With Lanthanum Carbonate (Fosrenol)

Patients who have been treated with Fosrenol for a minimum of 12 consecutive weeks and are receiving dialysis will be followed for 5 years to compare mortality, bone fractures and incidenc...

PubMed Articles [1223 Associated PubMed Articles listed on BioPortfolio]

Effect of Lanthanum Carbonate on All-Cause Mortality in Patients Receiving Maintenance Hemodialysis: a Meta-Analysis of Randomized Controlled Trials.

Hyperphosphatemia is common in patients on hemodialysis. The efficacy of lanthanum carbonate (LC) in the treatment of hyperphosphatemia in these patients remains controversial. The objective of this m...

Evaluation of the effect of lanthanum carbonate hydrate on the pharmacokinetics of roxadustat in non-elderly healthy adult male subjects.

Roxadustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor currently being investigated for the treatment of anemia in chronic kidney disease. Lanthanum carbonate is a phosphate binder that...

Nutritional status and survival of maintenance hemodialysis patients receiving lanthanum carbonate.

Hyperphosphatemia and poor nutritional status are associated with increased mortality. Lanthanum carbonate is an effective, calcium-free phosphate binder, but little is known about the long-term impac...

The effects of tenapanor on serum fibroblast growth factor 23 in patients receiving hemodialysis with hyperphosphatemia.

Elevated serum fibroblast growth factor 23 (FGF23) is strongly associated with cardiovascular risk and mortality. Tenapanor, an inhibitor of gastrointestinal sodium/hydrogen exchanger isoform 3, decre...

Colorimetric detection of glucose using lanthanum-incorporated MCM-41.

In this study, lanthanum-containing mesoporous MCM-41 (La-MCM-41) with different amount of lanthanum were synthesized and were used for colorimetric detection of glucose. As prepared La-MCM-41 were ch...

Medical and Biotech [MESH] Definitions

Lanthanum. The prototypical element in the rare earth family of metals. It has the atomic symbol La, atomic number 57, and atomic weight 138.91. Lanthanide ion is used in experimental biology as a calcium antagonist; lanthanum oxide improves the optical properties of glass.

A field of chemistry which pertains to chemical compounds or ions that do not contain the element carbon (with the exception of carbon dioxide and compounds containing a carbonate radical, e.g., calcium carbonate).

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

A polymeric amine that binds phosphate and is used to treat HYPERPHOSPHATEMIA in patients with kidney disease.

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

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