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Biobehavioral Effects of Topiramate on Cannabis-Related Outcomes in Adolescents

2014-07-23 21:09:26 | BioPortfolio

Summary

Cannabis use is a significant public health concern that disproportionately affect youth. Although promising psychosocial interventions are being developed, most youth do not benefit from these interventions alone. Given the clinical demand for effective treatments, the National Institute on Drug Abuse (NIDA) identified the critical need for data on the tolerability and potential efficacy of medications in adolescents. The purpose of this two-year study is to test if and how topiramate, a medication under intense study for treating several drugs of abuse, reduces cannabis use among teenagers. To this end, the investigators will randomize 56 nontreatment-seeking regular cannabis users (15 or 20 years old) to receive topiramate or placebo for 6 weeks. Youth will monitor their cannabis use for the 6-week period using handheld electronic diaries and complete assessments of reactivity to cannabis-related cues.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Cannabis Abuse

Intervention

Topiramate, Placebo

Location

Brown University, Center for Alcohol and Addiction Studies
Providence
Rhode Island
United States
02912

Status

Recruiting

Source

Brown University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:09:26-0400

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Abuse, overuse, or misuse of a substance by its injection into a vein.

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