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Interest of Plasmatic Concentration Dosage of PCSK9 in Coronary Syndrome

2014-08-27 03:14:12 | BioPortfolio

Summary

PCSK9 (Proprotein convertase subtilisin kexin type 9) is a proconvertase playing the key-role in LDL-Cholesterol (LDLC) metabolism inhibiting the LDL receptor by a post-transcriptional way.

On a functional plan, mutations "loss of function" of PCSK9 are linked to lower level of LDLC ant to a cardiovascular protection.

By the way, developing pharmacologic inhibitors of PCSK9 represent an important therapeutic issue to obtain, in association with statins, the target-values of LDLC. PCSK9 have the particularity to be secreted by liver and to circulate at hormonal concentration in plasma.

The circulating levels of PCSK9 are linked to concentrations of LDLC but also of triglycerides and plasmatic glucose.

Preliminary datas shows that PCSK9 concentrations are closely correlate to clinical score of seriousness and to the length of hospitalisation of polytrauma patients.

Nevertheless, no data are available on predictive value of PCSK9 concentrations concerning the severity of the coronary illness.

Study Design

Time Perspective: Prospective

Conditions

Acute Coronary Syndrome

Intervention

biological parameters dosage

Location

Nantes University hospital
Nantes
France
44000

Status

Not yet recruiting

Source

Nantes University Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:12-0400

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