The Impact of Chemotherapy on Memory Function and the Development of Traumatic Symptoms in Children With Cancer

2014-08-27 03:14:13 | BioPortfolio


Background: While treatment for pediatric cancer has improved significantly over the past 40 years, the neurotoxic side-effects of the chemotherapy agents themselves are now being recognized. Two drugs suspected of having acute impact on memory performance in children are methotrexate (MTX) and steroids (GCs). In addition, new evidence suggests that this neurotoxicity might actually protect these children from traumatization.

Working hypothesis and aims: This project aims to examine the acute impact of MTX and GC chemotherapy on memory performance in children and young adults with cancer, and the subsequent impact on the development of traumatic symptoms. We hypothesize that MTX and GCs will each produce acute declines in memory performance and that children with greater reductions in memory performance will have fewer traumatic symptoms.

Methods: The investigators will recruit 45 children being treated with MTX or GCs at Dana Children's Hospital. To determine acute impact on memory, a battery of memory tests will be administered before and after a cycle of MTX and before and after a cycle of GCs. In addition, traumatic symptoms will be assessed at each post-chemotherapy evaluation point Expected results: The investigators expect poorer memory performance after MTX and after GCs and that these performance declines will correlate with lower rates of traumatic symptoms.

Importance: The immediate impact of MTX and GCs on memory is not well known, especially in children. In addition, recent findings have led us to hypothesize that chemotherapy-induced deficits in memory function would paradoxically protect these patients from the traumatization often associated with cancer and its treatment. The proposed study will test this novel hypothesis for the first time.

Study Design

Observational Model: Cohort, Time Perspective: Prospective




Tel Aviv Sourasky Medical Center
Tel Aviv


Not yet recruiting


Tel-Aviv Sourasky Medical Center

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:14:13-0400

Clinical Trials [97 Associated Clinical Trials listed on BioPortfolio]

Examining Patient Preferences About the IBM Watson Oncology Clinical Decision Support System

The purpose of this study is to learn what cancer patients think about IBM Watson Oncology. IBM Watson Oncology is a computer program designed to help inform oncologists about the best che...

Support of the Sexual Health in Oncology

Implementation of sexual health support program in oncology department. This program is organized in 3 axes. One is to inform the side effects of treatment on sexual health. There is a co...

Clinical Concordance Study Between Watson for Oncology and Clinician Practice

At present, Watson for Oncology has been applied in 14 countries worldwide, including China, the United States, Holland, Thailand, India, Korea, Poland, Slovakia and Bangladesh. In a doubl...

Osteopathic Manipulative Treatment in Oncology Patients' Management

The aim of present study was to study the osteopathic manipulative effects on pain relief and quality of life improvement on hospitalized oncology geriatric patients. A non-randomized comp...

Survivorship Care Plans in a Community Oncology Practice

This is a two part observational study evaluating the feasibility of implementing an EHR-based model within a community oncology practice.

PubMed Articles [3377 Associated PubMed Articles listed on BioPortfolio]

Nonspecialty Nurse Education: Evaluation of the Oncology Intensives Initiative, an Oncology Curriculum to Improve Patient Care.

A community hospital combined its medical and surgical patients with cancer on one unit, which resulted in nurses not trained in oncology caring for this patient population.

The use of antidepressants in oncology: a review and practical tips for oncologists.

The use of psychotropic drugs, namely those with an antidepressant profile (ADs), is a mandatory part of an integrated treatment of psychiatric disorders among cancer patients. We aimed to synthetize ...

Development of a Virtual Radiation Oncology Clinic for training and simulation of errors in the radiation oncology workflow.

The State of Oncology Practice in America, 2018: Results of the ASCO Practice Census Survey.

To describe the US hematology and medical oncology practice landscape and to report findings of the sixth annual ASCO Oncology Practice Census survey.

American Society of Clinical Oncology Statement: Biosimilars in Oncology.

As many biosimilars come to market in the next several years, their use in oncology will play an important role in the future care of patients with cancer. ASCO is committed to providing education and...

Medical and Biotech [MESH] Definitions

Physicians specializing in MEDICAL ONCOLOGY or its sub-specialties of RADIATION ONCOLOGY or SURGICAL ONCOLOGY.

A subspecialty of medical oncology and radiology concerned with the radiotherapy of cancer.

A subspecialty of internal medicine concerned with the study of neoplasms.

A surgical specialty concerned with management of cancer.

The hospital department responsible for the administration and provision of diagnostic and therapeutic services for the cancer patient.

More From BioPortfolio on "The Impact of Chemotherapy on Memory Function and the Development of Traumatic Symptoms in Children With Cancer"

Quick Search


Relevant Topics

Pediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions at home and at school, pediatrics is a specialty. With ...

Head and neck cancers
Cancer can occur in any of the tissues or organs in the head and neck. There are over 30 different places that cancer can develop in the head and neck area. Mouth cancers (oral cancers)  - Mouth cancer can develop on the lip, the tongue, the floor...

  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...

Searches Linking to this Trial