Advertisement

Topics

Transtympanic Ringer's Lactate for the Prevention of Cisplatin Ototoxicity

2014-07-23 21:09:28 | BioPortfolio

Summary

Cisplatin and carboplatin induce ototoxicity manifested as sensorineural hearing loss, tinnitus, and/or vestibular disturbances. Ototoxicity is induced via damage to inner ear structures by reactive oxygen species. Previous animal studies demonstrated that transtympanic injection of Ringer's Lactate (RL) provided near complete otoprotective effect against cisplatin. The purpose of this study is to determine if transtympanic administration of Ringer's Lactate via a pressure equalising (PE) tube in patients undergoing platinum based chemotherapy treatment will prevent tinnitus, vestibular dysfunction and hearing loss especially at high frequencies. Pre- and post- chemotherapy treatment audiometry will be measured and statistically analysed for significance.

Study Design

Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention

Conditions

Hearing Loss

Intervention

Ringer's Lactate (0.03% Ciprofloxacin)

Location

Montreal General Hospital
Montreal
Quebec
Canada
H3G 1A1

Status

Recruiting

Source

McGill University Health Center

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:09:28-0400

Clinical Trials [830 Associated Clinical Trials listed on BioPortfolio]

Protection From Cisplatin Ototoxicity by Lactated Ringers

The purpose of this study is to determine if Lactated Ringer's solution is effective in patients undergoing chemotherapy with cisplatin for head and neck cancer in regards to cisplatin-ind...

Intrapartum Hydration

The purpose of this study is to determine that maternal hydration during labor with fluids containing glucose at a rate of 125 ml per hour does not affect the duration of labor compared to...

A Safety Study of Hemospan® in Total Prostatectomy Patients

This is a progressive dose escalation study designed to evaluate the safety of Hemospan compared to a standard crystalloid solution (Ringer's lactate) in elective surgery patients undergoi...

Clinical Trial of the "Living Well With Hearing Loss Workshop"

This study evaluates whether a 2 hour group session, "The Living Well with Hearing Loss Workshop," can successfully teach hard of hearing people how to best use hearing aids and a variety...

Does Intravenous Lactated Ringer Solution Raise Measured Serum Lactate?

Lactated Ringer's (LR) solution bolus is commonly administered in the emergency department setting to seriously ill patients. It is also common to obtain blood samples to determine serum l...

PubMed Articles [5935 Associated PubMed Articles listed on BioPortfolio]

CDC Grand Rounds: Promoting Hearing Health Across the Lifespan.

Globally, one in three adults has some level of measurable hearing loss, and 1.1 billion young persons are at risk for hearing loss attributable to noise exposure. Although noisy occupations such as c...

Factors Affecting Hearing Aid Adoption and Use: A Qualitative Study.

Despite a high prevalence of age-related hearing loss in older people, there is an unexplained low level of hearing aid adoption and use. Further research is required to determine the reason because h...

Splenic implant preservation after conservation in lactated Ringer´s solution.

to evaluate the morphology and function of autogenous splenic tissue implanted in the greater omentum, 24 hours after storage in Ringer-lactate solution.

Effect of Cochlear Implantation on Quality of Life in Adults with Unilateral Hearing Loss.

Patients with moderate-to-profound sensorineural hearing loss in 1 ear and normal hearing in the contralateral ear, known as unilateral hearing loss (UHL) or single-sided deafness (SSD), may experienc...

A controlled comparison of auditory steady-state responses and pure-tone audiometry in patients with hearing loss.

We performed a prospective interventional study to evaluate correlations between hearing thresholds determined by pure-tone audiometry (PTA) and auditory steady-state response (ASSR) testing in two ty...

Medical and Biotech [MESH] Definitions

Hearing loss due to exposure to explosive loud noise or chronic exposure to sound level greater than 85 dB. The hearing loss is often in the frequency range 4000-6000 hertz.

Hearing loss due to disease of the AUDITORY PATHWAYS (in the CENTRAL NERVOUS SYSTEM) which originate in the COCHLEAR NUCLEI of the PONS and then ascend bilaterally to the MIDBRAIN, the THALAMUS, and then the AUDITORY CORTEX in the TEMPORAL LOBE. Bilateral lesions of the auditory pathways are usually required to cause central hearing loss. Cortical deafness refers to loss of hearing due to bilateral auditory cortex lesions. Unilateral BRAIN STEM lesions involving the cochlear nuclei may result in unilateral hearing loss.

Hearing loss due to damage or impairment of both the conductive elements (HEARING LOSS, CONDUCTIVE) and the sensorineural elements (HEARING LOSS, SENSORINEURAL) of the ear.

Hearing loss without a physical basis. Often observed in patients with psychological or behavioral disorders.

Hearing loss in frequencies above 1000 hertz.

More From BioPortfolio on "Transtympanic Ringer's Lactate for the Prevention of Cisplatin Ototoxicity"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topic

Hearing
Hearing, auditory perception, or audition is the ability to perceive sound by detecting vibrations, changes in the pressure of the surrounding medium through time, through an organ such as the ear. Sound may be heard through solid, liquid, or gaseous mat...


Searches Linking to this Trial