Evaluation of Subjective Ratings of Appetite and Glucoregulation of a Low Calorie Diet Supplemented With a High Viscosity Polysaccharide (PolyGlycopleX - PGX)

2014-08-27 03:14:26 | BioPortfolio


The objective of the study is to compare subjective appetite ratings and after-meal and 24 hour blood glucose levels within overweight and obese female subjects consuming either a standardized 3 day low calorie diet supplemented with a viscous fibre known as PGX (treatment) or a rice flour (placebo control). Each treatment phase will be 3 days in length and separated by 3 week washout phase, so subjects will also be acting as their own control. Subjects will be randomized to either start with the low calorie diet with PGX or the low calorie diet supplemented with rice flour. We hypothesize that the 3 day LCD with PGX will elicit an improved appetite score compared to the 3 day LCD supplemented with the rice flour placebo control.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment


Appetite and Hunger, Suppression


PolyGlycopleX (PGX)


Canadian Centre for Functional Medicine
British Columbia


Not yet recruiting


Canadian Center for Functional Medicine

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:14:26-0400

Clinical Trials [407 Associated Clinical Trials listed on BioPortfolio]

Reduction of the Glycemic Index by a Novel Viscous Polysaccharide

Reductions of postprandial glucose levels have been demonstrated previously with the addition of a novel viscous polysaccharide (NVP) to a glucose drink and standard white bread. This stud...

Hunger and Satiety in Anorexia Nervosa

Anorexia means loss of appetite. But there is disagreement about whether the appetite is changed by the disease anorexia nervosa (AN). Appetite is a subjective essential sense, which is re...

What is the Maximum Amount of Carbohydrates That is Still Able to Induce Ketosis and Suppress Appetite?

Two dietary approaches, very low energy diets (VLEDs) and ketogenic low carbohydrate diets (KLCDs), have the ability to suppress appetite. The suppression of appetite typically observed du...

Effect of Escalating Doses of a Novel Viscous Polysaccharide on Postprandial Glycemia

To determine palatability and extent to which escalating doses of a novel highly viscous polysaccharide [NVP] reduces postprandial glycemia when added to a liquid and a solid meal.

Effect of Antipsychotics on Appetite Regulation

The purpose of this study is to evaluate changes in appetite-regulating hormones, body composition (weight, body fat%), and hunger ratings in persons early in treatment with one of four at...

PubMed Articles [2048 Associated PubMed Articles listed on BioPortfolio]

A Neural Circuit for the Suppression of Pain by a Competing Need State.

Hunger and pain are two competing signals that individuals must resolve to ensure survival. However, the neural processes that prioritize conflicting survival needs are poorly understood. We discovere...

Standardizing versus measuring food deprivation and hunger.

Eating in the absence of hunger in young children: The role of maternal feeding strategies.

Restrictive feeding strategies have been associated with increased eating in the absence of hunger in a small number of studies of young girls. The aim of the present study was to examine a broader ra...

The effect of hunger and satiety in the judgment of ethical violations.

Human history is studded with instances where instinctive motivations take precedence over ethical choices. Nevertheless, the evidence of any linking between motivational states and morality has never...

Infant hunger and satiety cues during the first two years of life: Developmental changes of within meal signalling.

Overfeeding in infancy may lead to overweight and obesity in later childhood. Mothers are advised to "tune in" to their infant's hunger, appetite and satiation cues to prevent overfeeding. The present...

Medical and Biotech [MESH] Definitions

Natural recurring desire for food. Alterations may induced by APPETITE DEPRESSANTS or APPETITE STIMULANTS.

Eating an excess amount of food in a short period of time, as seen in the disorder of BULIMIA NERVOSA. It is caused by an abnormal craving for food, or insatiable hunger also known as "ox hunger".

Physiologic mechanisms which regulate or control the appetite and food intake.

Agents that are used to decrease appetite.

Agents that are used to stimulate appetite. These drugs are frequently used to treat anorexia associated with cancer and AIDS.

More From BioPortfolio on "Evaluation of Subjective Ratings of Appetite and Glucoregulation of a Low Calorie Diet Supplemented With a High Viscosity Polysaccharide (PolyGlycopleX - PGX)"

Quick Search


Relevant Topics

Obesity is the condition in which excess fat has accumulated in the body (mostly in subcutaneous tissues). clinical obesity is considered to be present when a person has a BMI of over 30 (Oxford Dictionary of Medicine). It is becoming increasing common i...

Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

Searches Linking to this Trial