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Neural and Pharmacological Correlates of Intrusions in Patients With Posttraumatic Stress Disorder

2014-08-27 03:14:26 | BioPortfolio

Summary

There is evidence that glucocorticoids have an impact on intrusive memories in patients with posttraumatic stress disorder (PTSD). Hydrocortisone impairs intrusive memory retrieval whereas dexamethasone should strengthen intrusions in PTSD. We, the investigators, want to investigate (1) the effect of these two glucocorticoids on traumatic memories and (2) assess the neural correlates using the script-driven imagery paradigm in the functional magnetic resonance imaging (fMRI) scanner. We hypothesize that intrusive memories are less intensive under hydrocortisone-administration and more intensive under dexamethasone-administration comparing both to a placebo-condition. Regarding the neural activation pattern we expect higher activation in the hydrocortisone condition in the amygdala, the hippocampus and the medial prefrontal cortex compared to the placebo-condition and less activation in the dexamethasone-condition compared to the placebo-condition.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Basic Science

Conditions

Posttraumatic Stress Disorder

Intervention

10 mg HydrocortisoneHöchst, Dexamethasone, Placebo

Location

Central Institute of Mental Health, Dep. of Psychosomatic and Psychotherapeutic Medicine
Mannheim
Baden Württemberg6
Germany
68159

Status

Not yet recruiting

Source

Central Institute of Mental Health, Mannheim

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:26-0400

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