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LXRs, Cholesterol Metabolism and Uterine Dystocia

2014-08-27 03:14:27 | BioPortfolio

Summary

Despite the fact that a link between cholesterol and the myometrium has been clearly established, no study investigating aspects of cholesterol metabolism and uterine dystocia currently exists. This study is a pilot study whose aim is to test the hypothesis that an association between uterine dystocia and single-nucleotide polymorphisms (SNPs) in the genes coding for the LXRs.

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Conditions

Uterine Inertia

Intervention

Whole blood sampling

Location

Centre Hospitalier Universitaire de Nîmes
Nîmes
France
30029

Status

Recruiting

Source

Centre Hospitalier Universitaire de Nīmes

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:27-0400

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Medical and Biotech [MESH] Definitions

Failure of the UTERUS to contract with normal strength, duration, and intervals during childbirth (LABOR, OBSTETRIC). It is also called uterine atony.

Sampling of blood levels of the adrenocorticotropic hormone (ACTH) by withdrawal of blood from the inferior petrosal sinus. The inferior petrosal sinus arises from the cavernous sinus and runs to the internal jugular vein. Sampling of blood at this level is a valuable tool in the differential diagnosis of Cushing disease, Cushing syndrome, and other adrenocortical diseases.

A sampling methodology using small sample sizes when conducting surveys in small geographical or population-based areas or lots.

A method for diagnosis of fetal diseases by sampling the cells of the placental chorionic villi for DNA analysis, presence of bacteria, concentration of metabolites, etc. The advantage over amniocentesis is that the procedure can be carried out in the first trimester.

The use of embolizing agents to block the arterial blood supply to parts or all of the UTERUS. The procedures are done to control bleeding or to cause destruction of uterine tissues.

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Cholesterol
Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma. It is an important structural component of mammalian cell membranes, where it is establishes proper membrane permeability and fluidity. Cholesterol ...


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