Allogeneic Natural Killer (NK) Cells for Breast and Ovarian Cancer

2014-08-27 03:14:32 | BioPortfolio


This is a single center phase II trial designed to expand CD3/CD19 depleted allogeneic natural killer (NK) cells and induce disease response in patients with recurrent ovarian, fallopian tube, primary peritoneal cancer and advanced metastatic breast cancer using chemotherapy followed by haploidentical NK cells and IL-2.


The study will use a two-step enrollment procedure. Enrollment in stage I will include patients with an early stop if 3 or fewer patients have successful NK expansion. If 4 or more have expansion, enrollment will continue.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Ovarian Cancer


Fludarabine, Cyclophosphamide, Cyclosporine, Natural killer cells, IL-2


Masonic Cancer Center, University of Minnesota
United States


Not yet recruiting


Masonic Cancer Center, University of Minnesota

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:14:32-0400

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Haploidentical Natural Killer (NK) Cells in Patients With Relapsed Neuroblastoma Post Autologous Stem Cell Transplant

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PubMed Articles [29820 Associated PubMed Articles listed on BioPortfolio]

CXCR3-deficient natural killer cells fail to migrate to B16F10 melanoma cells.

Natural killer (NK) cells eliminate cancer cells in a contact-dependent manner. However, how NK cells find cancer cells remain unclear. Here, using time-lapse imaging, we investigated how individual N...

Natural Killer Cells Enhance Immune Checkpoint Blockade Efficacy.

Natural killer (NK) cell interactions with stimulatory dendritic cells (SDC) enhance immunotherapy.

Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis.

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Sesamolin affects both natural killer cells and cancer cells in order to create an optimal environment for cancer cell sensitization.

In our previous study, we demonstrated that sesamolin can increase the level of cancer cell susceptibility to natural killer (NK) cell mediated cytolysis when it treats cancer cells. The present study...

Natural killer cell-based immunotherapy: From transplantation toward targeting cancer stem cells.

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Medical and Biotech [MESH] Definitions

Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.

Cytolytic lymphocytes with the unique capacity of killing natural killer (NK)-resistant fresh tumor cells. They are INTERLEUKIN-2-activated NK cells that have no MAJOR HISTOCOMPATIBILITY COMPLEX restriction or need for antigen stimulation. LAK cells are used for ADOPTIVE IMMUNOTHERAPY in cancer patients.

A specialized subset of T-LYMPHOCYTES that exhibit features of INNATE IMMUNITY similar to that of NATURAL KILLER CELLS. They are reactive to glycolipids presented in the context of the major histocompatibility complex (MHC) class I-like molecule, CD1D ANTIGEN.

Receptors that are specifically found on the surface of NATURAL KILLER CELLS. They play an important role in regulating the cellular component of INNATE IMMUNITY.

Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.

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