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Respiratory Muscle Dysfunction in Critically Ill Patients

2014-07-23 21:09:31 | BioPortfolio

Summary

Respiratory muscle dysfunction in critically ill patients is associated with elevated morbidity, including prolonged weaning from mechanical ventilation. The causes for respiratory muscle dysfunction in these patients is poorly understood and no effective treatment is available.

The general hypothesis of the present study is that in critically ill mechanically ventilated subjects respiratory muscle dysfunctions results from loss of myosin induced by activation of proteolytic cascades.

Study Design

Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Conditions

Sepsis

Intervention

diaphragm muscle biopsy, Diaphragm muscle biopsy

Location

Radboud Universtity Nijmegen Medical Centre
Nijmegen
Netherlands
6500HB

Status

Active, not recruiting

Source

University Medical Center Nijmegen

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:09:31-0400

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Medical and Biotech [MESH] Definitions

A congenital abnormality characterized by the elevation of the DIAPHRAGM dome. It is the result of a thinned diaphragmatic muscle and injured PHRENIC NERVE, allowing the intra-abdominal viscera to push the diaphragm upward against the LUNG.

Conducting a biopsy procedure with the aid of a MEDICAL IMAGING modality.

An inherited congenital myopathic condition characterized by weakness and hypotonia in infancy and delayed motor development. Muscle biopsy reveals a condensation of myofibrils and myofibrillar material in the central portion of each muscle fiber. (Adams et al., Principles of Neurology, 6th ed, p1452)

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