Respiratory Muscle Dysfunction in Critically Ill Patients

2014-07-23 21:09:31 | BioPortfolio


Respiratory muscle dysfunction in critically ill patients is associated with elevated morbidity, including prolonged weaning from mechanical ventilation. The causes for respiratory muscle dysfunction in these patients is poorly understood and no effective treatment is available.

The general hypothesis of the present study is that in critically ill mechanically ventilated subjects respiratory muscle dysfunctions results from loss of myosin induced by activation of proteolytic cascades.

Study Design

Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science




diaphragm muscle biopsy, Diaphragm muscle biopsy


Radboud Universtity Nijmegen Medical Centre


Active, not recruiting


University Medical Center Nijmegen

Results (where available)

View Results


Published on BioPortfolio: 2014-07-23T21:09:31-0400

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Medical and Biotech [MESH] Definitions

A congenital abnormality characterized by the elevation of the DIAPHRAGM dome. It is the result of a thinned diaphragmatic muscle and injured PHRENIC NERVE, allowing the intra-abdominal viscera to push the diaphragm upward against the LUNG.

Conducting a biopsy procedure with the aid of a MEDICAL IMAGING modality.

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