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At present, there is some clinical data for different functional response to beta-blockers associated with beta-adrenergic receptor polymorphisms. But there has been no data reported, about the incidence of beta-adrenergic receptor polymorphism and association with beta-adrenergic receptor polymorphism and response to beta-blocker therapy in Korean heart failure (HF) subjects. This single-arm, open-label, multicentric study is designed with the purpose of analysing the association between genetic polymorphism of beta-adrenergic receptor and the effects of beta-blocker (bisoprolol) in Korean HF subjects.
Heart failure impairs the quality of life of an individual and is considered to be the main cause of morbidity and mortality. Prognosis of HF subjects depends on severity, age and sex. Subjects with HF require life long treatment. Pharmacological treatment aims to improve both the quality of life and survival of HF subjects.
- To analyse the association between genetic polymorphism of betaadrenergic receptor and the effects of beta-blocker (bisoprolol) in Korean HF subjects
- The frequency of polymorphism of beta adrenergic receptor in Korean HF subjects
The method involved in this study will be as follows:
- Initial evaluation of HF subjects
- Blood genomic deoxyribonucleic acid (DNA) isolation and collection
- Bisoprolol treatment as add on therapy with standard treatment for HF subject for 6 months
- Genotype of beta adrenergic receptor polymorphism
- Follow up evaluation of treated subjects
Bisoprolol will be given in a starting dose of 1.25 mg once daily for one week and if it is well tolerated, the dose will be increased to 2.5 mg for the next week and subsequently titrated up to the targeted dose of 10 mg per day.
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Chronic Heart Failure
The Catholic University of Korea Seoul St. Mary's Hospital, 505, Banpodong, SeoChoGu
Korea, Republic of
Published on BioPortfolio: 2014-08-27T03:14:33-0400
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