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Osteonecrosis in Children With Acute Lymphoblastic Leukemia

2014-08-27 03:14:33 | BioPortfolio

Summary

Acute lymphoblastic leukemia is the most common form of childhood cancer with current treatment survival rates approaching 80%. Improved outcomes show an increased number of survivors at risk for long-term treatment related side effects including osteonecrosis. Osteonecrosis, or bone death, is caused by blood supply loss to the bone causing pain and poor quality of life. The hips, shoulders, knees and ankles may be affected. Pain is the usual presenting symptom and may become severe requiring surgical decompression or replacement of the affected joint. Long-term effects including arthritis and progressive joint difficulties will not be known for decades. This study aims to determine the risk factors for developing osteonecrosis that will lead to information for earlier detection and prevention. The study will be the basis for future intervention and prevention trials.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Osteonecrosis

Location

Alberta Children's Hospital
Calgary
Alberta
Canada

Status

Recruiting

Source

Halton, Jacqueline, M.D.

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:33-0400

Clinical Trials [32 Associated Clinical Trials listed on BioPortfolio]

The British Osteonecrosis Study

The aim of this research is to examine the natural history of osteonecrosis in older children, teenagers and young adults with acute lymphoblastic leukaemia and lymphoblastic lymphoma with...

Medication-related Osteonecrosis of the Jaw (MRONJ) Registry

Approximately 500 patients will be included in this patient registry. Data collection includes demographics, clinical data of underlying disease and use of bisphosphonates, denosumab and a...

Mesenchymal Stem Cell for Osteonecrosis of the Femoral Head

Mesenchymal Stem Cell (MSC) has been shown to have immunosuppressive and repairing properties.The investigators will infuse expanded autologous MSC into patients with osteonecrosis of the ...

Predictive Factors for the Development of Osteonecrosis After the Treatment of the Developmental Dislocated Hip

Several risk factors for the development of osteonecrosis of the femoral head following treatment of developmental dislocated hip have been reported. The need for further research with a l...

Aspirin in the Prevention of Collapse in Osteonecrosis of the Hip

The purpose of this study is to determine if prolonged administration of low-dose aspirin will prevent the progression of early-stage osteonecrosis of the femoral head and may even reduce ...

PubMed Articles [89 Associated PubMed Articles listed on BioPortfolio]

Study on the risk factors for the misdiagnosis of femoral head osteonecrosis.

To evaluate the status and risk factors for the misdiagnosis of femoral head osteonecrosis, providing the basis for accurate diagnosis of osteonecrosis of femoral head.

Use of a generic violet light in the surgical management of medication-related osteonecrosis of the jaws: a technical note.

Fluorescence-guided surgery has been recommended for the diagnosis of bone margins in cases of mandibular osteonecrosis. In this article, we report a case in which a generic violet light was used in o...

Osteonecrosis in patients with acute lymphoblastic leukaemia: a national questionnaire study.

To establish prevalence, management and long-term outcomes of osteonecrosis (ON) in young people diagnosed with acute lymphoblastic leukaemia (ALL) between 2003 and 2011.

Drug Holiday Patterns and Bisphosphonate-Related Osteonecrosis of the Jaw.

There is limited evidence regarding the appropriate length of a bisphosphonate (BP) holiday to reduce the risk of osteonecrosis of the jaw (ONJ). In this cross-sectional study, we investigated the pop...

The influence of alendronate and tooth extraction on the incidence of osteonecrosis of the jaw among osteoporotic subjects.

Although bisphosphonate-related osteonecrosis of the jaw (ONJ) develops mainly after tooth extractions (TEs), the strength of the association between them and how the existence of the disease among bi...

Medical and Biotech [MESH] Definitions

Death of a bone or part of a bone, either atraumatic or posttraumatic.

Necrotic jaws or other maxillofacial skeleton necrosis associated with bisphosphonate use (see BISPHOSPHONATES). Injury, dental procedures, and trauma can trigger the necrotic process.

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