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Plavix, Prasugrel and Drug Eluting Stents Pilot Trial

2014-08-27 03:14:34 | BioPortfolio

Summary

- The purpose of this study is to determine the level of inhibition of platelet activation of an approved thienopyridine(clopidogrel or prasugrel) and aspirin regimen in the setting of drug eluting coronary stent implantation.

- In subjects with high residual levels of platelet reactivity after receiving either a maintenance or loading dose of either clopidogrel or prasugrel, a cross over of thienopyridine treatment to the alternate medication will occur.

- The study tests the hypothesis that adequate platelet inhibition will occur in subjects who have high levels of platelet reactivity and are subsequently switched from clopidogrel to prasugrel(loading or maintenance dose) without increased episodes of bleeding or MACE events at discharge and 30 days post Percutaneous Coronary Intervention (PCI).

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Coronary Artery Disease

Intervention

Loading Dose Arm, Maintenance Dose Arm

Location

St. Francis Hospital
Roslyn
New York
United States
11576

Status

Recruiting

Source

St. Francis Hospital, New York

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:34-0400

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