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Studies of pancreatic cancer etiology require a database of detailed personal and family history, with accompanying blood, and when available, fixed and fresh tissue. The aims of this project are to create a registry, and blood and tissue bank for individuals at risk for pancreatic cancer. The personal data will be derived by a study questionnaire, which will be completed by each study participant. Blood specimens will be drawn from each participant, a portion of which will be utilized to extract white blood cells for immortalization by Epstein-Barr virus infection. At the time of any surgical tumor resection,tumor and adjacent normal tissue will be requested from the pathologist in the Pathology Department. No additional tissue will be resected beyond that required for surgical management. The questionnaire data can be correlated with the biological information derived from the tissue specimens and will allow for future investigative studies of pancreatic cancer etiology and tumor biology. The long-term goals of the study are to advance the knowledge of the etiology and epidemiology of pancreatic cancer. It is anticipated that the knowledge derived will ultimately lead to improvements in the diagnosis, prevention, detection,and treatment of pancreatic cancer.
Pancreatic cancer is the fourth leading cause of death resulting from malignancy in both men and women. Approximately 30,500 individuals in the United States will be diagnosed with pancreatic cancer in 2004, and it is expected that 29,100 will die from the disease. The death rate and incidence are virtually identical. It is now known that 4-16% of pancreatic cancers are either inherited or familial. There is still much to be discovered about the etiology of inherited, familial, and sporadic pancreatic cancers. Studies of this type require a database of detailed personal and family history, with accompanying blood, and when available, fixed and fresh tissue. The aims of this project are to create a registry, and blood and tissue bank for individuals at risk for pancreatic cancer. The personal data will be derived by a study questionnaire. A portion of the collected white blood cells will be immortalized by EBV infection. At the time of any tumor resection, tumor and adjacent normal tissue will be requested from the Pathology Department. No additional tissue will be resected beyond that required for surgical management. The epidemiological data can be correlated with the biological information and will allow for future investigative studies of pancreatic cancer etiology and tumor biology. The long-term goals of the study are to advance the knowledge of the etiology and epidemiology of pancreatic cancer. It is anticipated and hypothesized that the knowledge derived will ultimately lead to improvements in the diagnosis, prevention, detection, and treatment of pancreatic cancer.
Observational Model: Cohort, Time Perspective: Prospective
Columbia University Medical Center
Published on BioPortfolio: 2014-08-27T03:14:38-0400
The NFPTR was established in 1994 to find the causes of pancreatic cancer. In brief, the investigators are interested in both the genetic and non-genetic causes of pancreatic cancer. The i...
Pancreatic cancer is a very aggressive cancer. Over the past 40 years there has not been much progress made in reducing deaths from this cancer. Recently, new models of pancreatic cancers ...
Pancreatic cancer often spreads through local invasion into local structures, including fat, blood vessels, nerves, and nearby organs (stomach, duodenum, spleen, bile duct). Local microsco...
The prognosis of pancreatic cancer is extremely poor, even in those patients who had underwent surgery, the 5-year survival is still less than 10%. Current guidelines recommend Gemcitabine...
This research study is evaluating a study drug to treat pancreatic exocrine insufficiency (PEI) during the first year after the diagnosis of pancreatic cancer while the participant is reco...
To analyze the expression of micro-RNA 143 (miRNA-143) in the patients with pancreatic cancer and to explore the influence of overexpression of miRNA-143 on pancreatic cancer cells.
The aim of this study was to assess the role of hepatitis B (HepB) infection in the causation of pancreatic cancer and the predictors of pancreatic cancer and related mortality.
CDK8 is associated with the transcriptional Mediator complex and has been shown to regulate several transcription factors implicated in cancer. As a pancreatic cancer oncogene, the role of CDK8 in can...
Pancreatic cancer is one of the most aggressive human malignancies and is associated with a dismal prognosis, which can be contributed to its atypical symptoms, metastatic propensity, and significant ...
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Star-shaped, myofibroblast-like cells located in the periacinar, perivascular, and periductal regions of the EXOCRINE PANCREAS. They play a key role in the pathobiology of FIBROSIS; PANCREATITIS; and PANCREATIC CANCER.
A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.
Extracts prepared from pancreatic tissue that may contain the pancreatic enzymes or other specific uncharacterized factors or proteins with specific activities. PANCREATIN is a specific extract containing digestive enzymes and used to treat pancreatic insufficiency.
C-type lectins that restrict growth of bacteria in the intestinal epithelia and have bactericidal activity against gram-positive and gram-negative bacteria. They also regulate proliferation and differentiation of KERATINOCYTES following injury. Human pancreatitis-associated protein-1 (Reg3a) is overexpressed by pancreatic ACINAR CELLS in patients with CHRONIC PANCREATITIS. It is also highly expressed by pancreatic, bladder, and gastrointestinal cancer cells and may serve as a diagnostic biomarker.
Pancreatitis Acute pancreatitis is inflammation of the pancreas caused by the release of activated pancreatic enzymes. Common triggers are biliary tract disease and chronic heavy alcohol intake. Diagnosis is based on clinical presentation...
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Head and neck cancers
Cancer can occur in any of the tissues or organs in the head and neck. There are over 30 different places that cancer can develop in the head and neck area. Mouth cancers (oral cancers) - Mouth cancer can develop on the lip, the tongue, the floor...