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Mycophenolate Mofetil in Systemic Lupus Erythematosus (MISSILE)

2014-07-23 21:09:34 | BioPortfolio

Summary

Systemic lupus erythematosus (SLE) is an independent risk factor for atherosclerosis. Endothelial dysfunction is the earliest marker of atherosclerosis and is measured by flow mediated dilation (FMD) of the brachial artery. The purpose of the study was to measure FMD in mild, stable SLE patients and look for change in FMD with the immunosuppressant drug mycophenolate mofetil (MMF).

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Systemic Lupus Erythematosus

Intervention

Mycophenolate mofetil, sugar pill

Location

Lupus Research Unit, St Thomas' Hospital
London
United Kingdom
SE1 7EH

Status

Completed

Source

Guy's and St Thomas' NHS Foundation Trust

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:09:34-0400

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Medical and Biotech [MESH] Definitions

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Antiphospholipid antibodies found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. The antibodies are detected by solid-phase IMMUNOASSAY employing the purified phospholipid antigen CARDIOLIPIN.

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