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The purpose of this study is to investigate if levosimendan improves contractile performance of the diaphragm in healthy subjects.
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
Respiratory Muscle Function
University Medical Center Nijmegen
Active, not recruiting
University Medical Center Nijmegen
Published on BioPortfolio: 2014-08-27T03:14:39-0400
Levosimendan is a relatively new drug that improves cardiac contractility in patients with heart failure. Its main mechanism of action is enhanced binding of calcium to the myocardial cont...
In the randomized, double-blind, placebo-controlled, parallel-group, multicentre study, ODM-109 capsules and placebo capsules for ODM-109 is administered for 48 weeks. The subjects are all...
To investigate changes in the concentration of glucose, lactate, pyruvate and glycerol in the extracellular fluid of the skeletal muscle following levosimendan administration in patients w...
Using an extensive set of both volitional and non-volitional tests of respiratory muscle function and strength it is the aim of this study to - identify disease-specific patterns of re...
The diaphragm forms the upper segment of the core structure. At the same time, the diaphragm muscle acts as the first muscle in the inspiratory function. The aim of this study was to inves...
Levosimendan, a calcium-sensitizing and Adenosine triphosphate-sensitive potassium channel opening inodilator, has the potential to improve cardiac function without increasing oxygen consumption. The ...
In sarcoidosis, muscle involvement is common, but mostly asymptomatic. Currently, little is known about respiratory muscle and diaphragm involvement and function in patients with sarcoidosis. Reduced ...
Recently a novel, time-saving respiratory muscle sprint-interval training (RMSIT) was developed. To test the extent to which RMSIT improves respiratory muscle performance compared to a conventional re...
The purpose of this review is to provide an overview on how interactions between control of breathing, respiratory load, and muscle function may lead to respiratory failure. The mechanisms involved va...
The impact of an acute bout of exercise, especially high-intensity exercise, on the function of mitochondrial respiratory complexes is not well understood, with potential implications for both the hea...
Methods and procedures for the diagnosis of diseases of the respiratory tract or its organs. It includes RESPIRATORY FUNCTION TESTS.
A respiratory function test that includes the maximal inspiratory pressure and maximal expiratory pressure. It is determined by SPIROMETRY that measures the patient's RESIDUAL VOLUME and TOTAL LUNG CAPACITY and assesses the strength of RESPIRATORY MUSCLES.
An operation that uses stimulated latissimus dorsi muscle (SKELETAL MUSCLE VENTRICLE) to assist cardiac function. The latissimus dorsi muscle is mobilized from the chest wall and moved into the thorax through the bed of the resected 2nd or 3rd rib. The muscle is then wrapped around the left and right ventricles and stimulated to contract during cardiac systole by means of an implanted burst-stimulator. (Stedman, 26th ed)
Thick triangular muscle in the SHOULDER whose function is to abduct, flex, and extend the arm. It is a common site of INTRAMUSCULAR INJECTIONS.
A family of transcription factors that control expression of a variety of nuclear GENES encoding proteins that function in the RESPIRATORY CHAIN of the MITOCHONDRIA.
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...
Of all the types of Dementia, Alzheimer's disease is the most common, affecting around 465,000 people in the UK. Neurons in the brain die, becuase 'plaques' and 'tangles' (mis-folded proteins) form in the brain. People with Al...
Asthma COPD Cystic Fibrosis Pneumonia Pulmonary Medicine Respiratory Respiratory tract infections (RTIs) are any infection of the sinuses, throat, airways or lungs. They're usually caused by viruses, but they can also ...