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Effect of Levosimendan on Respiratory Muscle Function in Healthy Subjects

2014-08-27 03:14:39 | BioPortfolio

Summary

The purpose of this study is to investigate if levosimendan improves contractile performance of the diaphragm in healthy subjects.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Conditions

Respiratory Muscle Function

Intervention

Levosimendan

Location

University Medical Center Nijmegen
Nijmegen
Gelderland
Netherlands
6525 GA

Status

Active, not recruiting

Source

University Medical Center Nijmegen

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:39-0400

Clinical Trials [2061 Associated Clinical Trials listed on BioPortfolio]

Effects of Levosimendan on Diaphragm Function in Mechanically Ventilated Patients

Levosimendan is a relatively new drug that improves cardiac contractility in patients with heart failure. Its main mechanism of action is enhanced binding of calcium to the myocardial cont...

Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALS

In the randomized, double-blind, placebo-controlled, parallel-group, multicentre study, ODM-109 capsules and placebo capsules for ODM-109 is administered for 48 weeks. The subjects are all...

Effects of Levosimendan on Cellular Metabolic Alterations in Patients With Septic Shock

To investigate changes in the concentration of glucose, lactate, pyruvate and glycerol in the extracellular fluid of the skeletal muscle following levosimendan administration in patients w...

Respiratory Muscle Strength and Function in Neuromuscular Disorders and Chronic Obstructive Pulmonary Disease

Using an extensive set of both volitional and non-volitional tests of respiratory muscle function and strength it is the aim of this study to - identify disease-specific patterns of re...

Assessment of Trunk Muscle Endurance, Respiratory Functions and Respiratory Muscle Strength in Healthy Individuals

The diaphragm forms the upper segment of the core structure. At the same time, the diaphragm muscle acts as the first muscle in the inspiratory function. The aim of this study was to inves...

PubMed Articles [12705 Associated PubMed Articles listed on BioPortfolio]

Levosimendan in Cardiac Surgery: Evaluating the Evidence.

Levosimendan, a calcium-sensitizing and Adenosine triphosphate-sensitive potassium channel opening inodilator, has the potential to improve cardiac function without increasing oxygen consumption. The ...

Respiratory muscle involvement in sarcoidosis.

In sarcoidosis, muscle involvement is common, but mostly asymptomatic. Currently, little is known about respiratory muscle and diaphragm involvement and function in patients with sarcoidosis. Reduced ...

Effects of Sprint-Interval and Endurance Respiratory Muscle Training Regimens.

Recently a novel, time-saving respiratory muscle sprint-interval training (RMSIT) was developed. To test the extent to which RMSIT improves respiratory muscle performance compared to a conventional re...

The Pathophysiology of Respiratory Failure: Control of Breathing, Respiratory Load, and Muscle Capacity.

The purpose of this review is to provide an overview on how interactions between control of breathing, respiratory load, and muscle function may lead to respiratory failure. The mechanisms involved va...

Acute High-Intensity Exercise Impairs Skeletal Muscle Respiratory Capacity.

The impact of an acute bout of exercise, especially high-intensity exercise, on the function of mitochondrial respiratory complexes is not well understood, with potential implications for both the hea...

Medical and Biotech [MESH] Definitions

Methods and procedures for the diagnosis of diseases of the respiratory tract or its organs. It includes RESPIRATORY FUNCTION TESTS.

A respiratory function test that includes the maximal inspiratory pressure and maximal expiratory pressure. It is determined by SPIROMETRY that measures the patient's RESIDUAL VOLUME and TOTAL LUNG CAPACITY and assesses the strength of RESPIRATORY MUSCLES.

An operation that uses stimulated latissimus dorsi muscle (SKELETAL MUSCLE VENTRICLE) to assist cardiac function. The latissimus dorsi muscle is mobilized from the chest wall and moved into the thorax through the bed of the resected 2nd or 3rd rib. The muscle is then wrapped around the left and right ventricles and stimulated to contract during cardiac systole by means of an implanted burst-stimulator. (Stedman, 26th ed)

Thick triangular muscle in the SHOULDER whose function is to abduct, flex, and extend the arm. It is a common site of INTRAMUSCULAR INJECTIONS.

A family of transcription factors that control expression of a variety of nuclear GENES encoding proteins that function in the RESPIRATORY CHAIN of the MITOCHONDRIA.

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