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Effect of Levosimendan on Respiratory Muscle Function in Healthy Subjects

2014-08-27 03:14:39 | BioPortfolio

Summary

The purpose of this study is to investigate if levosimendan improves contractile performance of the diaphragm in healthy subjects.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Conditions

Respiratory Muscle Function

Intervention

Levosimendan

Location

University Medical Center Nijmegen
Nijmegen
Gelderland
Netherlands
6525 GA

Status

Active, not recruiting

Source

University Medical Center Nijmegen

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:39-0400

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Effects of Levosimendan on Diaphragm Function in Mechanically Ventilated Patients

Levosimendan is a relatively new drug that improves cardiac contractility in patients with heart failure. Its main mechanism of action is enhanced binding of calcium to the myocardial cont...

Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALS

In the randomized, double-blind, placebo-controlled, parallel-group, multicentre study, ODM-109 capsules and placebo capsules for ODM-109 is administered for 48 weeks. The subjects are all...

Effects of Levosimendan on Cellular Metabolic Alterations in Patients With Septic Shock

To investigate changes in the concentration of glucose, lactate, pyruvate and glycerol in the extracellular fluid of the skeletal muscle following levosimendan administration in patients w...

Respiratory Muscle Strength and Function in Neuromuscular Disorders and Chronic Obstructive Pulmonary Disease

Using an extensive set of both volitional and non-volitional tests of respiratory muscle function and strength it is the aim of this study to - identify disease-specific patterns of re...

Impact of a Structural Phonation Training on Respiratory Muscle Function in Patients With Structural Heart Disease

Most patients with complex congenital heart disease and cardiomyopathy from acquired heart disease have reduced exercise capacity. Exercise capacity is associated with respiratory muscle s...

PubMed Articles [12613 Associated PubMed Articles listed on BioPortfolio]

Depleted iron stores are associated with inspiratory muscle weakness independently of skeletal muscle mass in men with systolic chronic heart failure.

Skeletal and respiratory muscle dysfunction constitutes an important pathophysiological feature of heart failure (HF). We assessed the relationships between respiratory muscle function, skeletal muscl...

Efficacy of bedside respiratory muscle training in patients with stroke: A randomized controlled trial.

Inspiratory and the expiratory muscles are important for effective respiratory function. This study aimed to investigate the efficacy of bedside respiratory muscle training on pulmonary function and s...

NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice.

Skeletal muscle from mdx mice is characterized by increased Nox2 ROS, altered microtubule network, increased muscle stiffness, and decreased muscle/respiratory function. While microtubule de-tyrosinat...

Respiratory muscle training for multiple sclerosis.

Multiple sclerosis (MS) is a chronic disease of the central nervous system, affecting approximately 2.5 million people worldwide. People with MS may experience limitations in muscular strength and end...

The Reversible Covalent Reaction of Levosimendan with Cardiac Troponin-C in vitro and in situ.

The development of calcium sensitizers for the treatment of systolic heart failure presents difficulties including judging the optimal efficacy and the specificity to target cardiac muscle. The thin f...

Medical and Biotech [MESH] Definitions

Methods and procedures for the diagnosis of diseases of the respiratory tract or its organs. It includes RESPIRATORY FUNCTION TESTS.

A respiratory function test that includes the maximal inspiratory pressure and maximal expiratory pressure. It is determined by SPIROMETRY that measures the patient's RESIDUAL VOLUME and TOTAL LUNG CAPACITY and assesses the strength of RESPIRATORY MUSCLES.

An operation that uses stimulated latissimus dorsi muscle (SKELETAL MUSCLE VENTRICLE) to assist cardiac function. The latissimus dorsi muscle is mobilized from the chest wall and moved into the thorax through the bed of the resected 2nd or 3rd rib. The muscle is then wrapped around the left and right ventricles and stimulated to contract during cardiac systole by means of an implanted burst-stimulator. (Stedman, 26th ed)

Thick triangular muscle in the SHOULDER whose function is to abduct, flex, and extend the arm. It is a common site of INTRAMUSCULAR INJECTIONS.

A family of transcription factors that control expression of a variety of nuclear GENES encoding proteins that function in the RESPIRATORY CHAIN of the MITOCHONDRIA.

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