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The primary objective of the study is to evaluate the efficacy of SPD489 compared to placebo on executive function (self-regulation) behaviors in adults with ADHD who report clinically significant impairment of executive function behavior in their everyday environment, as measured by the self-report Behavior Rating Inventory of Executive Function - Adult Version (BRIEF-A) Global Executive Composite (GEC) T-score.
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
ADHD Specifically With Executive Function Impairment
Clinical Study Centers, LLC
Shire Pharmaceutical Development
Published on BioPortfolio: 2014-08-27T03:14:40-0400
To evaluate the efficacy of SPD489 for the treatment of executive function impairments (EFI) when used as an adjunct to stable, standard therapy in the setting of partial or full remission...
The purpose of this study is to determine if an investigational treatment is effective in improving the total score on the ADHD-RS-IV Preschool Version in children 4-5 years old diagnosed ...
The goal of the current project is to assess the efficacy of Central Executive Training (CET) for youth with ADHD. CET is a new, computerized training intervention that targets specific co...
Feasibility study of Central Executive Training (CET) for ADHD. The goal of the current project is to develop and assess the feasibility, acceptability, engagement, and usability of a nove...
The goal of this study is to provide a new, early treatment approach for preschoolers with ADHD, which could facilitate the EF developing well to achieve better outcome.
Attention-deficit/hyperactivity disorder (ADHD) frequently co-occurs with substance use disorders and has some overlapping symptoms with mild cognitive impairment, including executive functions. We wa...
Book Review: Teenagers with ADD, ADHD and executive function deficits: A guide for parents and professionals Zeigler Dendy Chris A. ( 2017 ). Teenagers with ADD, ADHD and executive function deficits: A guide for parents and professionals ( 3rd ed .). Toronto, ON : Woodbine House via University of Toronto Press Guidance Centre . 359 pp . US$26.95 . ISBN: 978-1-60613-281-4.
Measures of executive function (EF), such as the Behavior Rating Inventory of Executive Function, distinguish children with attention-deficit/hyperactivity disorder (ADHD) from control subjects, but l...
Autobiographical memories are memories for personally experienced life events. Previous research has revealed individual differences in the ability to recall specific memories that happened at a parti...
Cerebral microbleeds (CMBs) have been identified as an important manifestation and diagnostic marker of cerebrovascular disease, but there are also some controversies about the impact of CMBs on cogni...
A set of cognitive functions that controls complex, goal-directed thought and behavior. Executive function involves multiple domains, such as CONCEPT FORMATION, goal management, cognitive flexibility, INHIBITION control, and WORKING MEMORY. Impaired executive function is seen in a range of disorders, e.g., SCHIZOPHRENIA; and ADHD.
A neuropsychological test designed to assess EXECUTIVE FUNCTION typically assigned to the FRONTAL LOBE (e.g., abstract thinking, and strategic planning). The subjects are asked to sort numbered response cards according to different principles and to alter their approach during testing.
Impairment of the vestibular function of both inner ears which can cause difficulties with balance, gait, VERTIGO, and visual blurring.
Ratings that express in numerical values the degree of impairment or abnormality in the function of specific organs.
Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.
Psychiatry is the study of mental disorders and their diagnosis, management and prevention. Conditions include schizophrenia, severe depression and panic disorders among others. There are pharmaceutical treatments as well as other therapies to help...