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A Study of Genomic-guided 'Standard-of-care' Chemotherapy for in Advanced Gastric Cancer Patients

2014-08-27 03:14:40 | BioPortfolio

Summary

The investigators hypothesize that the response signature would enable us to stratify patients according to predicted drug response to standard-of-care therapy and hence increase treatment response in an enriched patient group.

Study Design

Primary Purpose: Treatment

Conditions

Advanced Gastric Cancer

Intervention

Cisplatin, TS-1 and oxaliplatin

Location

National University Hospital
Singapore
Singapore

Status

Recruiting

Source

National University Hospital, Singapore

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:40-0400

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Medical and Biotech [MESH] Definitions

That portion of the stomach remaining after gastric surgery, usually gastrectomy or gastroenterostomy for cancer of the stomach or peptic ulcer. It is a common site of cancer referred to as stump cancer or carcinoma of the gastric stump.

A proto-oncogene protein and member of the Wnt family of proteins. It is frequently up-regulated in human GASTRIC CANCER and is a tumor marker (TUMOR MARKERS, BIOLOGICAL) of gastric and COLORECTAL CANCER.

A deoxycytidine derivative and fluorouracil PRODRUG that is used as an ANTINEOPLASTIC ANTIMETABOLITE in the treatment of COLON CANCER; BREAST CANCER and GASTRIC CANCER.

An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.

An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer.

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