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Hyperbaric Oxygen Therapy for Acute Domestic Carbon Monoxide (CO) Poisoning

2014-07-23 21:09:35 | BioPortfolio

Summary

Carbon monoxide poisoning still places a burden on the healthcare system worldwide. While oxygen therapy is the cornerstone treatment, the role and practical modalities of hyperbaric oxygen therapy (HBO) remain controversial. This study aimed at comparing one session of HBO at 2 absolute atmosphere followed by 4 hours of normobaric oxygen therapy to 6 hours of normobaric oxygen therapy in adult victims of acute domestic carbon monoxide poisoning and without coma.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Conditions

Carbon Monoxide Poisoning

Intervention

normobaric oxygen therapy, Hyperbaric oxygen therapy

Location

Raymond Poincaré Hospital
Garches
France
92380

Status

Terminated

Source

University of Versailles

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:09:35-0400

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Medical and Biotech [MESH] Definitions

Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)

Toxic asphyxiation due to the displacement of oxygen from oxyhemoglobin by carbon monoxide.

The therapeutic intermittent administration of oxygen in a chamber at greater than sea-level atmospheric pressures (three atmospheres). It is considered effective treatment for air and gas embolisms, smoke inhalation, acute carbon monoxide poisoning, caisson disease, clostridial gangrene, etc. (From Segen, Dictionary of Modern Medicine, 1992). The list of treatment modalities includes stroke.

Inhalation of oxygen aimed at restoring toward normal any pathophysiologic alterations of gas exchange in the cardiopulmonary system, as by the use of a respirator, nasal catheter, tent, chamber, or mask. (From Dorland, 27th ed & Stedman, 25th ed)

Enzymes that catalyze the joining of two molecules by the formation of a carbon-oxygen bond. EC 6.1.

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