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A Study of MM-111 in Combination With (Herceptin) Trastuzumab in Patients With Advanced Her2 Positive Breast Cancer

2014-08-27 03:14:50 | BioPortfolio

Summary

This is an open-label Phase 1-2 trial of MM-111 in combination with Herceptin (trastuzumab).

Description

Phase 1: In this portion of the study, safety and tolerability of the MM-111 + Herceptin (trastuzumab) combination will be evaluated and the recommended Phase 2 dose will be determined.

Phase 2: In this portion of the study, efficacy of MM-111 in combination with Herceptin (trastuzumab) will be evaluated.

Study Design

Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Her2 Positive Breast Cancer

Intervention

MM-111 and Herceptin (trastuzumab)

Location

Gabrail Cancer Center
Canton
Ohio
United States
44718

Status

Recruiting

Source

Merrimack Pharmaceuticals

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:50-0400

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PubMed Articles [18766 Associated PubMed Articles listed on BioPortfolio]

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Medical and Biotech [MESH] Definitions

A humanized monoclonal antibody against the ERBB-2 RECEPTOR (HER2). As an ANTINEOPLASTIC AGENT, it is used to treat BREAST CANCER where HER2 is overexpressed.

Abnormal accumulation of lymph in the arm, shoulder and breast area associated with surgical or radiation breast cancer treatments (e.g., MASTECTOMY).

Metastatic breast cancer characterized by EDEMA and ERYTHEMA of the affected breast due to LYMPHATIC METASTASIS and eventual obstruction of LYMPHATIC VESSELS by the cancer cells.

A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)

A deoxycytidine derivative and fluorouracil PRODRUG that is used as an ANTINEOPLASTIC ANTIMETABOLITE in the treatment of COLON CANCER; BREAST CANCER and GASTRIC CANCER.

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