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Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (2)

2014-08-27 03:14:50 | BioPortfolio

Summary

To evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional cross-links within or between collagen fibers using UVA light and the photo- mediator riboflavin. The purpose of this study is to generate data for presentation at medical meetings and for peer-review publication

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Keratoconus

Location

LA Sight
Los Angeles
California
United States

Status

Recruiting

Source

Innovative Medical

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:50-0400

Clinical Trials [78 Associated Clinical Trials listed on BioPortfolio]

Objective and Subjective Diagnostic Parameters in the Fellow Eye of Unilateral Keratoconus

patients with keratoconus in one eye and forme fruste keratoconus in the fellow eye compared to normal subjects .the patients were examined by schemipflug imaging system (Pentacam)

Prevalence of Keratoconus in Inflammatory Bowel Diseases

A retrospective study has shown the association between the inflammatory bowel diseases (IBD) and the presence of a keratoconus. This new study will measure the prevalence of keratoconus a...

The Possible Role of Thyroxine in Keratoconus Development

Keratoconus (KC) is a corneal ectatic disorders, with incidence rate 1 per 50,000 among the population. Hormonal imbalances may be associated with KC as it affects the corneal metabolism. ...

The Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study

To describe the clinical course of keratoconus and to describe the relationships among its visual and physiological manifestations, including high- and low-contrast visual acuity, corneal ...

Treatment of Keratoconus With Advanced CXL-II

The purpose of this study is to determine whether individualized, topography-based corneal crosslinking for keratoconus can improve the optical outcomes of the treatment.

PubMed Articles [68 Associated PubMed Articles listed on BioPortfolio]

Epidemiology of keratoconus in different countries.

The scientific problem of epidemiology of keratoconus in different countries is covered in the article. The results of original studies were analyzed and a conclusion has been drawn that keratoconus i...

Corneal Biomechanics in Unilateral Keratoconus and Fellow Eyes with a Scheimpflug-based Tonometer.

Before the appearance of evident keratoconus, corneal biomechanical changes may be detectable. Here, these properties are analyzed to detect any difference that could help in the early recognition of ...

Macular and Peripapillary Choroidal Thickness in Patients With Keratoconus.

To investigate and compare macular and peripapillary choroidal thickness and profiles of patients with keratoconus and age-matched controls and correlate subfoveal choroidal thickness with keratoconus...

Evaluation of galectin-1 and galectin-3 as prospective biomarkers in keratoconus.

To evaluate the expression of β-galactoside-binding proteins galectin (Gal)-1 and Gal-3 in patients with keratoconus (KC) and postcorneal collagen cross-linking (CXL) treatment in vitro.

Rare, potentially pathogenic variants in 21 keratoconus candidate genes are not enriched in cases in a large Australian cohort of European descent.

Many genes have been suggested as candidate genes for keratoconus based on their function, their proximity to associated polymorphisms or due to the identification of putative causative variants withi...

Medical and Biotech [MESH] Definitions

A noninflammatory, usually bilateral protrusion of the cornea, the apex being displaced downward and nasally. It occurs most commonly in females at about puberty. The cause is unknown but hereditary factors may play a role. The -conus refers to the cone shape of the corneal protrusion. (From Dorland, 27th ed)

The measurement of curvature and shape of the anterior surface of the cornea using techniques such as keratometry, keratoscopy, photokeratoscopy, profile photography, computer-assisted image processing and videokeratography. This measurement is often applied in the fitting of contact lenses and in diagnosing corneal diseases or corneal changes including keratoconus, which occur after keratotomy and keratoplasty.

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