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The Effect of Probiotics on the Clearance of the Human Papillomavirus and on Cytological Lesions Caused by the Virus

2014-08-27 03:14:50 | BioPortfolio

Summary

Aim: In this project proposition the investigators would like to examine the effect of immune modulation by probiotics on the clearance of HPV-infections.

This study provides a model for viral infection but also for cancer precursors. This would be an excellent model (and the only possible short-term model) to examine an effect on cancer precursors. Cancer precursors (cytological abnormalities such as L-SIL) are a scientifically accepted surrogate endpoint for cervical cancer, for example in HPV-vaccine studies.

Research question: Does daily intake of probiotics lead to a better immune-response in HPV-infected women, i.e. does it facilitate clearance of the virus and/or regression of cytological lesions?

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Conditions

HPV-related Cytological Abnormalities on PAP Smear (LSIL)

Intervention

probiotic drinkers

Location

Veronique Verhoeven
Wilrijk
Belgium
2610

Status

Recruiting

Source

Universiteit Antwerpen

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:50-0400

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