Track topics on Twitter Track topics that are important to you
PURPOSE: This phase II trial is studying how well ursodiol works in treating patients with Barrett esophagus or low-grade dysplasia.
- To evaluate the ability of ursodiol to reverse oxidative DNA damage in the esophageal epithelium of subjects with Barrett esophagus (BE) and low-grade dysplasia (LGD).
- To determine the effects of ursodiol on gastric bile acid composition and on cell proliferation of these patients.
OUTLINE: This is a multicenter study.
Patients receive oral ursodiol twice daily for 6 months in the absence of disease progression or unacceptable toxicity.
Tissue and gastric fluid samples are collected during standard endoscopy, at baseline and after completion of study for biomarker analysis by IHC and high-performance liquid chromatography tandem mass spectrometry.
After completion of study therapy, patients are followed up for 2 weeks.
Masking: Open Label, Primary Purpose: Prevention
ursodiol, high performance liquid chromatography, immunohistochemistry staining method, laboratory biomarker analysis, mass spectrometry
Not yet recruiting
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:14:50-0400
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about the affect of body mass index on the way anticancer drugs work in the bod...
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cance...
RATIONALE: Erlotinib and sirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase I/II trial is studying the side effects a...
RATIONALE: Biological therapies, such as 1-methyl-D-tryptophan, may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by stimulating the immune syst...
RATIONALE: Studying samples of blood and tumor tissue in the laboratory from patients with cancer may help doctors learn more about changes that occur in DNA and help doctors understand ho...
Development of a high performance liquid chromatography method with fluorescence detection for the routine quantification of tamoxifen, endoxifen, and 4-hydroxytamoxifen in plasma from breast cancer patients.
To date, several methods for quantification of tamoxifen and its metabolites have been developed, most of which employ liquid chromatography tandem-mass spectrometry (LC-MS/MS). These methods are high...
To establish a high performance liquid chromatography (HPLC) method for the determination of 8-methoxypsoralen (8-MOP) in mouse plasma and apply it to a pharmacokinetic study of 8-MOP.
The ionic liquids have special features and, hence, called as liquid electrolytes, ionic melts, ionic glasses, fused salts, liquid salts, ionic fluids, designer solvents, green, and future solvents. A...
A method has been developed and validated for analysis of zoledronic acid (ZOL) and its related substances by ion-pair reversed-phase high performance liquid chromatography with evaporative light scat...
Hydroxylamine (NH2OH) is widely used in pharmaceutical intermediates and final drug substances synthesis. Since hydroxylamine is a well-known genotoxic impurity compound that needs to be controlled do...
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A method of separation of two or more substances by repeated distribution between two immiscible liquid phases that move past each other in opposite directions. It is a form of liquid-liquid chromatography. (Stedman, 25th ed)
A CHROMATOGRAPHY method using supercritical fluid, usually carbon dioxide under very high pressure (around 73 atmospheres or 1070 psi at room temperature) as the mobile phase. Other solvents are sometimes added as modifiers. This is used both for analytical (SFC) and extraction (SFE) purposes.
Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.
Chromatographic techniques in which the mobile phase is a liquid.
Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...
Barrett’s esophagus is a condition in which the tissue lining the esophagus—the muscular tube that carries food and liquids from the mouth to the stomach—is replaced by tissue that is similar to the intestinal lining. This process is ca...
In a clinical trial or interventional study, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices; procedures; or change...