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PURPOSE: This phase II trial is studying how well ursodiol works in treating patients with Barrett esophagus or low-grade dysplasia.
- To evaluate the ability of ursodiol to reverse oxidative DNA damage in the esophageal epithelium of subjects with Barrett esophagus (BE) and low-grade dysplasia (LGD).
- To determine the effects of ursodiol on gastric bile acid composition and on cell proliferation of these patients.
OUTLINE: This is a multicenter study.
Patients receive oral ursodiol twice daily for 6 months in the absence of disease progression or unacceptable toxicity.
Tissue and gastric fluid samples are collected during standard endoscopy, at baseline and after completion of study for biomarker analysis by IHC and high-performance liquid chromatography tandem mass spectrometry.
After completion of study therapy, patients are followed up for 2 weeks.
Masking: Open Label, Primary Purpose: Prevention
ursodiol, high performance liquid chromatography, immunohistochemistry staining method, laboratory biomarker analysis, mass spectrometry
Not yet recruiting
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:14:50-0400
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Lipid Peroxidation Process in Meat and Meat Products: A Comparison Study of Malondialdehyde Determination between Modified 2-Thiobarbituric Acid Spectrophotometric Method and Reverse-Phase High-Performance Liquid Chromatography.
The aim of this work was to compare the methods of malondialdehyde detection, as the main secondary product of the lipid peroxidation process, in meat and meat products. Malondialdehyde measurements w...
Three polyacetylenes were isolated and purified from Platycodon grandiflorum A. DC for the first time by high-speed counter-current chromatography using a two-phase solvent system composed of hexane/e...
Various immunoassays have been used for cyclosporine A (CsA) analysis in human whole blood; however, they could not fully satisfy the requirements of criteria for accuracy and specificity in CsA measu...
A simple and green ionic liquid-based vortex-forced matrix solid phase dispersion (IL-VFMSPD) method was presented to simultaneously extract 5-hydroxymethyl furfurol (5-HMF) and iridoid glycosides in ...
Cycloserine (CYC) is a second line antitubercular drug that is used for the treatment of multidrug resistant tuberculosis (MDR-TB) along with other antitubercular agents and is often used in developin...
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A method of separation of two or more substances by repeated distribution between two immiscible liquid phases that move past each other in opposite directions. It is a form of liquid-liquid chromatography. (Stedman, 25th ed)
A CHROMATOGRAPHY method using supercritical fluid, usually carbon dioxide under very high pressure (around 73 atmospheres or 1070 psi at room temperature) as the mobile phase. Other solvents are sometimes added as modifiers. This is used both for analytical (SFC) and extraction (SFE) purposes.
Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.
Chromatographic techniques in which the mobile phase is a liquid.
Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...
Barrett’s esophagus is a condition in which the tissue lining the esophagus—the muscular tube that carries food and liquids from the mouth to the stomach—is replaced by tissue that is similar to the intestinal lining. This process is ca...
In a clinical trial or interventional study, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices; procedures; or change...