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Randomized Trial of Gemcitabine/Cisplatin Versus S-1/Cisplatin in Advanced Biliary Cancer

2014-08-27 03:14:51 | BioPortfolio

Summary

The purpose of this study is to compare the efficacy between gemcitabine/cisplatin and S-1/cisplatin in the first-line treatment in advanced biliary tract cancer.

Description

Standard chemotherapy regimen for biliary tract cancer(BTC) has not been established due to the difficulty associated with performing clinical trials in this field.

Gemcitabine or fluoropyrimidines, including 5-fluorouracil and S-1, are routinely used for BTC chemotherapy. The European Society for Medical Oncology (ESMO) and the National Comprehensive Cancer Network guidelines published in 2009 recommend either gemcitabine-based or fluoropyrimidine-based chemotherapy or clinical trials for first-line treatment.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Metastatic Biliary Tract Cancer

Intervention

Gemcitabine, Cisplatin, S-1, Cisplatin

Location

Gyeongsang University Hospital
Jinju
Gyeongsang Namdo
Korea, Republic of
660-702

Status

Not yet recruiting

Source

Gyeongsang National University Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:51-0400

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Medical and Biotech [MESH] Definitions

An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.

Tumors or cancer in the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

Abnormal passage in any organ of the biliary tract or between biliary organs and other organs.

Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.

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