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Comparison of Botulinum Toxin and Sphincterotomy in the Treatment of Chronic Anal Fissure

2014-07-23 21:09:42 | BioPortfolio

Summary

Intra-sphincteric injection of botulinum toxin seems to be a reliable option causing temporary alleviation of sphincter spasm and allowing the fissure to heal. study is to compare the outcome of surgical sphincterotomy and botulinum toxin injection treatments in patients with uncomplicated chronic anal fissure.

Description

consecutive patients with uncomplicated chronic anal fissure who had failed conservative treatment were randomized to receive either intra-sphincteric injection of botulinum toxin (BT) or lateral internal sphincterotomy (LIS). Postoperative pain relief, healing of fissure, continence scores and fissure relapse during 18 weeks of follow up was the outcomes assessed.

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Conditions

Pain

Intervention

conservative lateral internal sphincterotomy, Intra-sphincteric Botulinum-toxin injection

Location

Department of General Surgery-Theodore Bilharz Research Institute ,
Cairo
Egypt

Status

Completed

Source

Theodor Bilharz Research Institute

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:09:42-0400

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Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type C which is neurotoxic to ANIMALS, especially CATTLE, but not humans. It causes dissociation of ACTIN FILAMENTS.

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type D which is neurotoxic to ANIMALS, especially CATTLE, but not humans.

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type E which is neurotoxic to humans and animals.

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type F which is neurotoxic to humans and animals.

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