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Tesetaxel as Second-line Therapy for Patients With Advanced Gastric Cancer

2014-08-27 03:14:53 | BioPortfolio

Summary

Tesetaxel is an orally administered chemotherapy agent of the taxane class. The dose of a chemotherapy agent is typically based on the patient's body surface area. Flat dosing is desirable in the clinical setting. Pharmacokinetic and safety data from completed Phase II studies suggest that administration of tesetaxel at a flat dose is appropriate. This study is being undertaken to evaluate the efficacy and safety of tesetaxel administered as second-line therapy at a flat dose to patients with advanced gastric cancer.

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Adenocarcinoma of the Stomach

Intervention

Tesetaxel

Location

Northwestern Medical Faculty Foundation
Chicago
Illinois
United States
60611

Status

Recruiting

Source

Genta Incorporated

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:53-0400

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Medical and Biotech [MESH] Definitions

A condition where the stomach wall becomes thickened, rubbery and loses its ability to distend. The stomach assumes a "leather bottle" shape. It is most often seen in adenocarcinoma of the stomach. The term is often used synonymously with diffuse adenocarcinoma of the stomach.

A lesion with cytological characteristics associated with invasive adenocarcinoma but the tumor cells are confined to the GLANDULAR EPITHELIAL CELLS of origin. Adenocarcinoma in situ of the CERVIX and the LUNG are the most common.

An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)

An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)

An adenocarcinoma with a hard (Greek skirrhos, hard) structure owing to the formation of dense connective tissue in the stroma. (From Dorland, 27th ed)

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