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The general aim of the current study is to describe the effect of pregabalin on colonic and sensory functions in healthy individuals.
1. To quantify the effect of describe the mode of action of pregabalin on colonic sensory and motor functions in visceral hyperalgesia on healthy adults.
3. To determine effective dose of pregabalin in reducing colonic sensation ratings and increasing pain thresholds during visceral hyperalgesia in healthy adults.
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Human Colonic Physiology
Published on BioPortfolio: 2014-08-27T03:14:57-0400
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Dopamine regulates gastrointestinal mucosal barrier. Mucus plays important roles in protection of intestinal mucosa. Here, the regulatory effect of dopamine on rat colonic mucus secretion was investig...
Inflammation of the COLONIC DIVERTICULA, generally with abscess formation and subsequent perforation.
Chronic or recurrent colonic disorders without an identifiable structural or biochemical explanation. The widely recognized IRRITABLE BOWEL SYNDROME falls into this category.
A pathological condition characterized by the presence of a number of COLONIC DIVERTICULA in the COLON. Its pathogenesis is multifactorial, including colon aging, motor dysfunction, increases in intraluminal pressure, and lack of dietary fibers.
Functional obstruction of the COLON leading to MEGACOLON in the absence of obvious COLONIC DISEASES or mechanical obstruction. When this condition is acquired, acute, and coexisting with another medical condition (trauma, surgery, serious injuries or illness, or medication), it is called Ogilvie's syndrome.
Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.
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Pain is defined by the International Association for the Study of Pain as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage”. Some illnesses can be excruci...