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Pregabalin and Colonic Function

2014-08-27 03:14:57 | BioPortfolio

Summary

The general aim of the current study is to describe the effect of pregabalin on colonic and sensory functions in healthy individuals.

Description

Specific Objectives

1. To quantify the effect of describe the mode of action of pregabalin on colonic sensory and motor functions in visceral hyperalgesia on healthy adults.

2. To describe assess the potential relationship between any analgesic properties of pregabalin and its effect on compliance in healthy adults.

3. To determine effective dose of pregabalin in reducing colonic sensation ratings and increasing pain thresholds during visceral hyperalgesia in healthy adults.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)

Conditions

Human Colonic Physiology

Intervention

Pregabalin

Location

Mayo Clinic
Rochester
Minnesota
United States
55905

Status

Recruiting

Source

Mayo Clinic

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:57-0400

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PubMed Articles [13108 Associated PubMed Articles listed on BioPortfolio]

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The objective is using saliva instead of plasma for pregabalin therapeutic drug monitoring (TDM) since saliva reflects the free non-protein bound drug concentration, simple and noninvasive sampling, c...

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Tryptamine, a tryptophan-derived monoamine similar to 5-hydroxytryptamine (5-HT), is produced by gut bacteria and is abundant in human and rodent feces. However, the physiologic effect of tryptamine i...

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Medical and Biotech [MESH] Definitions

Inflammation of the COLONIC DIVERTICULA, generally with abscess formation and subsequent perforation.

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