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The company has temporarily suspended recruitment into and treatment of patients in all recruiting Stimuvax® (BLP25 liposome vaccine) trials worldwide, including EMR63325-008. This is a precautionary measure due to a suspected unexpected serious adverse reaction (SUSAR) in this trial with Stimuvax (Phase II Multiple Myeloma trial EMR63325-008), while we are diligently investigating the cause of this adverse event.
More information can be accessed here: http://www.merck.de/en/media/extNewsDetail.html?newsId=E01571A622782EADC12576EE00702854&newsType=1
L-BLP25 is believed to induce a MUC1-specific T-cell response after vaccination. The primary purpose of this study consists of the ascertainment of a MUC1-specific T-cell response in a specific subject population.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
L-BLP25, cyclophosphamide prior to first vaccination, L-BLP25, cyclophosphamide prior to each vaccination, L-BLP25 minus cyclophosphamide
Please call/email Central Contact for Study Location information
Published on BioPortfolio: 2014-08-27T03:14:57-0400
The company has temporarily suspended recruitment into and treatment of patients in all recruiting Stimuvax® (BLP25 liposome vaccine) trials worldwide, including STRIDE EMR 200038-010. Th...
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This is a multicenter, open label, phase II randomized controlled study that will evaluate the efficacy of carfilzomib and dexamethasone in combination with cyclophosphamide in R/R MM pati...
To evaluate the risk of post-transplantation malignancy in renal transplant recipients exposed to pre-transplantation cyclophosphamide for treatment of glomerular nephropathy (GN).
We report comparative efficacy between high-dose cyclophosphamide (HDCyC), low-dose cyclophosphamide (LDCyC), mycophenolate mofetil (MMF) and rituximab in patients with lupus nephritis (LN).
Cyclophosphamide (CP) has been known as an anticancer drug with several side effects on various organs such as a male reproductive system that can cause infertility.
Chemotherapy can cause early menopause or infertility in women and have a profound negative impact on the quality of life of young female cancer survivors. Various factors are known to influence the r...
The medicinal mushroom Cordyceps militaris has been reported to possess anticancer and immunomodulatory effects. We investigated the immunostimulatory effects of culture supernatant of C. militaris (...
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
An institutional policy of granting authority to health personnel to perform procedures on patients or to remove organs from cadavers for transplantation unless an objection is registered by family members or by the patient prior to death. This also includes emergency care of minors without prior parental consent.
A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE.
Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
In a clinical trial or interventional study, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices; procedures; or change...