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Thalidomide for Patients With Mild to Moderate Alzheimer's Disease

2014-08-27 03:14:58 | BioPortfolio

Summary

This is a 24-week, randomized, double-blind, placebo-controlled study of the effect of thalidomide and placebo on CSF (cerebral spinal fluid) and plasma biomarkers in patients with mild to moderate Alzheimer's disease. This study will evaluate the effects of 24 weeks of treatment with Thalidomide on plasma biomarkers.

Description

A lumbar puncture will be done before treatment (baseline), and at 24 weeks to collect CSF for the quantification of biomarkers. As an exploratory effort, we will test the effects of thalidomide on the same biomarkers in the plasma and will determine if detectable changes mirror changes observed in the CSF.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Conditions

Alzheimer's Disease

Intervention

Thalidomide

Location

Banner Sun Health Research Institute
Sun City
Arizona
United States
85351

Status

Recruiting

Source

Banner Health

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:58-0400

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