Evaluation of a Low-fluoride Anticaries Toothpaste

2014-08-27 03:14:58 | BioPortfolio


The purpose of this trial is to evaluate the anticaries remineralizing potential of a toothpaste containing 500 ppm fluoride plus fTCP technology relative to a commercially available toothpaste via a double-blind cross-over in situ (or intra-oral) clinical model, whereby approved human participants will wear an orthodontic appliance fitted with an enamel specimen for the duration of a leg (28 days). There will be two test legs.

Study Design

Observational Model: Case-Crossover, Time Perspective: Prospective


Tooth Abnormality


Fluorides, Topical


Dental Diagnostic Clinic within the University of Texas Health Science Center
San Antonio
United States


Not yet recruiting


Indiana Nanotech, LLC

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:14:58-0400

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Medical and Biotech [MESH] Definitions

Fluorides, usually in pastes or gels, used for topical application to reduce the incidence of DENTAL CARIES.

Any change in the hue, color, or translucency of a tooth due to any cause. Restorative filling materials, drugs (both topical and systemic), pulpal necrosis, or hemorrhage may be responsible. (Jablonski, Dictionary of Dentistry, 1992, p253)

An abnormality in the direction of a TOOTH ERUPTION.

Inorganic fluorides of tin. They include both stannic fluoride (tin tetrafluoride) and stannous fluoride (tin difluoride). The latter is used in the prevention of dental caries.

The pathologic wearing away of the tooth substance by brushing, bruxism, clenching, and other mechanical causes. It is differentiated from TOOTH ATTRITION in that this type of wearing away is the result of tooth-to-tooth contact, as in mastication, occurring only on the occlusal, incisal, and proximal surfaces. It differs also from TOOTH EROSION, the progressive loss of the hard substance of a tooth by chemical processes not involving bacterial action. (From Jablonski, Dictionary of Dentistry, 1992, p2)

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