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Efficacy and Safety of Lercanidipine and Enalapril in Patients With Essential Hypertension

2014-08-27 03:14:58 | BioPortfolio

Summary

The poupose of this study is to evaluate the efficacy and safety of various dosage combinations of lercanidipine (10 and 20 mg)and enalapril (10 and 20 mg) in comparison with their respective components and with placebo.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Conditions

Essential Hypertension

Intervention

Placebo, Lercanidipine, Lercanidipine, Enalapril, Enalapril, Lercanidipine + Enalapril, Lercanidipine + Enalapril, Lercanidipine + Enalapril, Lercanidipine + Enalapril

Location

Hôpital de la Pitié-Salpétrière
Paris
France

Status

Recruiting

Source

Recordati Industria Chimica e Farmaceutica S.p.A.

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:58-0400

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Medical and Biotech [MESH] Definitions

One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS that is used to treat hypertension.

The active metabolite of ENALAPRIL and a potent intravenously administered angiotensin-converting enzyme inhibitor. It is an effective agent for the treatment of essential hypertension and has beneficial hemodynamic effects in heart failure. The drug produces renal vasodilation with an increase in sodium excretion.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

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