Oral Versus Intravenous Hydration to Prevent Contrast Induced Nephropathy

2014-08-27 03:14:59 | BioPortfolio


The increased risk for contrast-induced nephropathy (CIN) in patients with chronic kidney disease (CKD) undergoing coronary angiography (CAG) has been established. Current and historical data on CIN prevention strategies have shown wide variation with respect to the optimal type, route and timing of these therapies. We investigate the role for oral hydration and/or oral sodium bicarbonate administration compared to intravenous hydration and/or sodium bicarbonate in patients with CKD undergoing CAG.


This is a single center study randomizing patients with CKD undergoing CAG into 4 groups: 1) Intravenous normal saline, 2) Intravenous normal saline and intravenous bicarbonate, 3) oral hydration, and 4) oral hydration and oral bicarbonate. The primary endpoint was the occurrence of contrast-medium-induced nephropathy defined as greater than 25% increase in serum creatinine from baseline or an absolute increase of 0.5 mg/dL from baseline at 72 hours following exposure to radiocontrast. Secondary endpoints include the length of hospitalization and in-house mortality.

Study Design

Allocation: Randomized, Control: Historical Control, Endpoint Classification: Bio-equivalence Study, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Prevention


Contrast Induced Nephropathy


Oral hydration, Oral sodium bicarbonate, Intravenous Hydration, Intravenous sodium bicarbonate


The Western Pennsylvania Hospital
United States




The Western Pennsylvania Hospital

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:14:59-0400

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