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Oral Versus Intravenous Hydration to Prevent Contrast Induced Nephropathy

2014-08-27 03:14:59 | BioPortfolio

Summary

The increased risk for contrast-induced nephropathy (CIN) in patients with chronic kidney disease (CKD) undergoing coronary angiography (CAG) has been established. Current and historical data on CIN prevention strategies have shown wide variation with respect to the optimal type, route and timing of these therapies. We investigate the role for oral hydration and/or oral sodium bicarbonate administration compared to intravenous hydration and/or sodium bicarbonate in patients with CKD undergoing CAG.

Description

This is a single center study randomizing patients with CKD undergoing CAG into 4 groups: 1) Intravenous normal saline, 2) Intravenous normal saline and intravenous bicarbonate, 3) oral hydration, and 4) oral hydration and oral bicarbonate. The primary endpoint was the occurrence of contrast-medium-induced nephropathy defined as greater than 25% increase in serum creatinine from baseline or an absolute increase of 0.5 mg/dL from baseline at 72 hours following exposure to radiocontrast. Secondary endpoints include the length of hospitalization and in-house mortality.

Study Design

Allocation: Randomized, Control: Historical Control, Endpoint Classification: Bio-equivalence Study, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Prevention

Conditions

Contrast Induced Nephropathy

Intervention

Oral hydration, Oral sodium bicarbonate, Intravenous Hydration, Intravenous sodium bicarbonate

Location

The Western Pennsylvania Hospital
Pittsburgh
Pennsylvania
United States
15224

Status

Completed

Source

The Western Pennsylvania Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:14:59-0400

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