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Gabapentin for the Treatment of Pruritus Caused by Burn Injuries in Children

2014-07-23 21:09:45 | BioPortfolio

Summary

Children with healing burns often suffer from pruritus that may continue for many months. Pruritus can be very distressing to the child and can interfere with sleep, activities of daily living, and rehabilitation therapy. Additionally, constant scratching of skin grafts may result in damage that requires further surgery, thus putting the patient at additional risk and adding to health care costs. Although the size of the burn injury is a risk factor for pruritus, almost 50% of patients with small burn injuries reported moderate or severe pruritus.

Description

Gabapentin has been shown to be effective for the treatment of pruritus in adult patients with brachioradial pruritus, uraemic pruritus and pruritus of unknown origin. Although the specific mechanism is unknown, the end result is the downregulation of excitatory neurotransmitter release and decrease in neuronal hyperexcitability.

The primary objective of this study is evaluating the effectiveness of gabapentin in reducing the severity of pruritus in children with burn injuries.

Study Design

Control: Uncontrolled, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Pruritus

Intervention

Gabapentin

Location

The Hospital for Sick Children
Toronto
Ontario
Canada

Status

Recruiting

Source

The Hospital for Sick Children

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:09:45-0400

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Medical and Biotech [MESH] Definitions

Agents, usually topical, that relieve itching (pruritus).

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Inflammation of the VULVA. It is characterized by PRURITUS and painful urination.

Intense itching of the external female genitals.

Inflammation of the VULVA and the VAGINA, characterized by discharge, burning, and PRURITUS.

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