The Impact of Dietary Flavanols on the Gut Microflora

2014-08-27 03:15:03 | BioPortfolio


The primary propose of this study is to determine the impact of flavanol-rich cocoa on the growth of the human gut microbiota.


A randomised, placebo-controlled, double-blind, cross-over human intervention study will be conducted in 20 healthy human volunteers to test the impact of a high-flavanol containing meal on the growth of the large intestinal bacteria (microflora). The high flavanol test meal will contain 495 mg of flavanols and the low flavanol control will contain 23 mg of flavanols. The two intervention diets are otherwise matched for macro- and micronutrient content. Changes in the gut microbiota will be determined by measuring bacterial population levels in human faecal material using 16S rRNA targeted oligonucleotide probes and fluorescence in situ hybridization. A number of other biochemical and physiological measures will be recorded including blood glucose, lipoproteins, cytokine levels and blood pressure.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science


Intestinal Bacteria Growth


Low flavanol cocoa beverage, High flavanol cocoa beverage


University of Reading
United Kingdom




University of Reading

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:15:03-0400

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Medical and Biotech [MESH] Definitions

Food product prepared from fermenting, roasting, and grinding the seeds of the COCOA plant.

A beverage prepared from SOYBEANS.

A tree of the family Sterculiaceae (or Byttneriaceae), usually Theobroma cacao, or its seeds, which after fermentation and roasting, yield cocoa and chocolate.

A beverage made by FERMENTATION of black tea and/or green tea.

Fermented juice of fresh grapes or of other fruit or plant products used as a beverage.

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