Advertisement

Topics

The Impact of Dietary Flavanols on the Gut Microflora

2014-08-27 03:15:03 | BioPortfolio

Summary

The primary propose of this study is to determine the impact of flavanol-rich cocoa on the growth of the human gut microbiota.

Description

A randomised, placebo-controlled, double-blind, cross-over human intervention study will be conducted in 20 healthy human volunteers to test the impact of a high-flavanol containing meal on the growth of the large intestinal bacteria (microflora). The high flavanol test meal will contain 495 mg of flavanols and the low flavanol control will contain 23 mg of flavanols. The two intervention diets are otherwise matched for macro- and micronutrient content. Changes in the gut microbiota will be determined by measuring bacterial population levels in human faecal material using 16S rRNA targeted oligonucleotide probes and fluorescence in situ hybridization. A number of other biochemical and physiological measures will be recorded including blood glucose, lipoproteins, cytokine levels and blood pressure.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Conditions

Intestinal Bacteria Growth

Intervention

Low flavanol cocoa beverage, High flavanol cocoa beverage

Location

University of Reading
Reading
Berkshire
United Kingdom
RG2 9AR

Status

Completed

Source

University of Reading

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:03-0400

Clinical Trials [583 Associated Clinical Trials listed on BioPortfolio]

Cocoa Ileostomy Study

There is substantial interest in the potential role of chocolate and its primary bioactive component; flavan-3-ol, (-)-epicatechin, in both the prevention and management of cardiovascular ...

Cocoa Flavanol and Coronary Vasomotion Vascular Function in Patients With Coronary Artery Disease

The aim of the present study is to investigate whether the ingestion of a cocoa flavanol-containing drink compared to a flavanol-free drink, improves coronary vasomotion and platelet funct...

Intake-dependent Effect of Cocoa Flavanol Absorption, Metabolism and Excretion in Humans

A randomized, double-masked and cross-over dietary intervention study in healthy young adult males to evaluate the concentration of F-derived metabolites in plasma and urine after single a...

The Effect of Cocoa Flavanol on the BOLD Response and Cognitive Function in Type 1 Diabetes

Type 1 Diabetes (T1D) is associated with microvascular changes in the brain, which can cause cognitive dysfunction. Cocoa flavanols (CF) can stimulate vasodilation, resulting in enhanced c...

Flavanol Absorption, Metabolism and Excretion From Fruit-based Drinks and Other Food Matrixes

Dietary intervention study in healthy adult males to evaluate concentration of flavanol metabolites in plasma and urine after single acute intakes of flavanols from different fruit-based d...

PubMed Articles [13485 Associated PubMed Articles listed on BioPortfolio]

Short-term supplementation with flavanol-rich cocoa improves lipid profile, antioxidant status and positively influences the AA/EPA ratio in healthy subjects.

We evaluated the short-term effects of a flavanol-rich cocoa (FRC) on lipid profile and selected oxidative stress biomarkers such as oxidized low-density lipoprotein (oxLDL), glutathione (GSH), and F-...

Hazelnut and cocoa spread improves flow-mediated dilatation in smokers.

Hazelnut and cocoa spread is an Italian product containing cocoa and hazelnut. Several epidemiological studies suggest that cocoa and hazelnuts cocoa exert beneficial cardiovascular effects. To invest...

Effects of Maturity at Harvest and Fermentation Conditions on Bioactive Compounds of Cocoa Beans.

Cocoa beans and cocoa products contain considerable amounts of bioactive compounds. Harvesting cocoa fruit too early or too late may have effects on the phenolic and alkaloid concentrations of the coc...

Description of Child and Adolescent Beverage and Anthropometric Measures According to Adolescent Beverage Patterns.

Our objective is to retrospectively describe longitudinal beverage intakes and anthropometric measures according to adolescent beverage patterns. Data were collected from Iowa Fluoride Study participa...

Climate change could threaten cocoa production: Effects of 2015-16 El Niño-related drought on cocoa agroforests in Bahia, Brazil.

Climate models predict a possible increase in the frequency of strong climate events such as El Niño-Southern Oscillation (ENSO), which in parts of the tropics are the cause of exceptional droughts, ...

Medical and Biotech [MESH] Definitions

Food product prepared from fermenting, roasting, and grinding the seeds of the COCOA plant.

A beverage prepared from SOYBEANS.

A tree of the family Sterculiaceae (or Byttneriaceae), usually Theobroma cacao, or its seeds, which after fermentation and roasting, yield cocoa and chocolate.

A beverage made by FERMENTATION of black tea and/or green tea.

Fermented juice of fresh grapes or of other fruit or plant products used as a beverage.

More From BioPortfolio on "The Impact of Dietary Flavanols on the Gut Microflora"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Nutrition
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

Cytokine
Cytokines include chemokines, lymphokines, and monokines. Cells of the immune system communicate with one another by releasing and responding to chemical messengers called cytokines. These proteins are secreted by immune cells and act on other cells to...


Searches Linking to this Trial