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Dextromethorphan and Silymarin in Chronic Kidney Disease (CKD) Patients

2014-08-27 03:15:04 | BioPortfolio

Summary

The investigators test the renal and cardiovascular protective effects dextromethorphan and silymarin on patients with the proteinuric chronic kidney diseases, who enrolled in our clinical trial, had progressing kidney diseases and merit aggressive anti-inflammatory therapy.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Proteinuria

Intervention

Dextromethorphan, Silymarin, sugar pill

Location

National Cheng-Kung University Hospital
Taian
Taiwan

Status

Active, not recruiting

Source

National Cheng-Kung University Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:04-0400

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Medical and Biotech [MESH] Definitions

A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.

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Dextro form of levorphanol. It acts as a noncompetitive NMDA receptor antagonist, among other effects, and has been proposed as a neuroprotective agent. It is also a metabolite of DEXTROMETHORPHAN.

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